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| Name |
Shigella Dysenteriae Toxin |
EINECS | N/A |
| CAS No. | 75757-64-1 | Density | N/A |
| PSA | N/A | LogP | N/A |
| Solubility | N/A | Melting Point |
N/A |
| Formula | N/A | Boiling Point | N/A |
| Molecular Weight | 0 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | A poison by parenteral, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors. | Risk Codes |
 A poison.:; |
| Molecular Structure |
|
Hazard Symbols | A poison. |
| Synonyms |
Vero cell toxin;S. dysenteriae toxin;Shigella dysenteriae type I toxin;Toxin, shigella dysenteriae;Shigella toxin (Shigella dysenteriae); |
Shigella Dysenteriae Toxin Chemical Properties
Chemistry informtion about Shigella Dysenteriae Toxin (CAS NO.75757-64-1) is:
Synonyms: Shiga Toxin ; Toxin, Shigella Dysenteriae
MF: C54H99NO18
MW: 1050.3598
Density: 1.23 g/cm3
Flash Point: 641.3 °C
Boiling Point: 1136.7 °C at 760 mmHg
Enthalpy of Vaporization: 189.33 kJ/mol
Following is the molecular structure of Shigella Dysenteriae Toxin (CAS NO.75757-64-1) is:
Shigella Dysenteriae Toxin Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 250ng/kg (0.00025mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) | Journal of Immunology. Vol. 130, Pg. 380, 1983. |
| mouse | LD50 | intravenous | 450ng/kg (0.00045mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) | Journal of Immunology. Vol. 130, Pg. 380, 1983. |
| mouse | LDLo | parenteral | 2ug/kg (0.002mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) behavioral: tremor behavioral: convulsions or effect on seizure threshold | Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985. |
| rabbit | LD50 | intravenous | 2200pg/kg (0.0000022mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) | Journal of Immunology. Vol. 130, Pg. 380, 1983. |
| rabbit | LDLo | parenteral | 600ng/kg (0.0006mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) gastrointestinal: nausea or vomiting | Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985. |
| rat | LDLo | parenteral | 1ug/kg (0.001mg/kg) | peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) gastrointestinal: nausea or vomiting | Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985. |
Shigella Dysenteriae Toxin Safety Profile
A poison by parenteral, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.
Shigella Dysenteriae Toxin Analytical Methods
Shigella Dysenteriae Toxin (CAS NO.75757-64-1) act to inhibit protein synthesis within target cells by a mechanism similar to that of ricin toxin produced by Ricinus communis. After entering a cell, the protein functions as an N-glycosidase, cleaving several nucleobases from the RNA that comprises the ribosome, thereby halting protein synthesis.
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