Sitagliptin (486460-32-6),Sitagliptin (486460-32-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Sitagliptin
CAS No.:
486460-32-6
Molecular Structure:
Formula:
C₁₆H₁₅F₆N₅O
Molecular Weight:
407.32
Synonyms:
1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-(9CI);(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine;(3R)-3-amino-1-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo(4,3-a)pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-;
Density:
1.61 g/cm³
Boiling Point:
529.9 °C at 760 mmHg
Flash Point:
274.3 °C

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Chemistry

IUPAC Name: (3R)-3-Amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Molecular Formula: C₁₆H₁₅F₆N₅O
Molecular Weight: 407.32 g/mol
SMILES: Fc1cc(c(F)cc1F)C[C@@H](N)CC(=O)N3Cc2nnc(n2CC3)C(F)(F)F Copy
InChI: InChI=1/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
Classification Code: Dipeptidyl-Peptidase IV Inhibitors; Enzyme Inhibitors; Protease Inhibitors
Product Categories: API; Pharmaceutical intermediate
Index of Refraction: 1.59
Molar Refractivity: 85.17 cm³
Molar Volume: 252.3 cm³
Surface Tension: 42.4 dyne/cm
Density: 1.61 g/cm³
Flash Point: 274.3 °C
Enthalpy of Vaporization: 80.51 kJ/mol
Boiling Point: 529.9 °C at 760 mmHg
Vapour Pressure of Sitagliptin (CAS NO.486460-32-6): 2.59E-11 mmHg at 25 °C

History

Sitagliptin was approved by the U.S. Food and Drug Administration (FDA) on October 17, 2006 and is marketed in the US as Januvia by Merck & Co. On April 2, 2007, the FDA approved an oral combination of sitagliptin and metformin marketed in the US as Janumet.

Uses

Sitagliptin (CAS NO.486460-32-6) is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2.

Specification

Sitagliptin (CAS NO.486460-32-6), its Synonyms are Januvia ; 1,2,4-Triazolo(4,3-a)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)- ; Xelevia .