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TERGITOL XH
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TERGITOL XH

 EINECS N/A
CAS No. 106392-12-5 Density g/cm3
PSA 46.15000 LogP 3.33230
Solubility N/A Melting Point 57-61 °C
Formula (C3H6O•C2H4O)x Boiling Point 32.9°Cat760mmHg
Molecular Weight 332.48 Flash Point 55.2°C
Transport Information N/A Appearance N/A
Safety Low toxicity by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating vapors. Risk Codes 61
Molecular Structure Molecular Structure of 106392-12-5 (TERGITOL(TM)XH(NONIONIC)) Hazard Symbols T
Synonyms

TERGITOL(TM)XH(NONIONIC);f108;f127;f77;f87;f88;methyloxiranepolymerwithoxiraneblock;oxirane,methyl-,polymerwithoxirane,block

 

TERGITOL XH Chemical Properties

IUPAC Name: 2-Methyloxirane ; Oxirane
The MF of Poloxamer (CAS NO.106392-12-5) is C5H10O2.

                              
The MW of Poloxamer (CAS NO.106392-12-5) is 102.13.
Synonyms of Poloxamer (CAS NO.106392-12-5): 1,2-Propyleneglycol, ethoxylated and propoxylated 
Enthalpy of Vaporization: 27.35 kJ/mol
Flash Point: 55.2 °C   
Boiling Point: 32.9 °C

TERGITOL XH Uses

 Poloxamer (CAS NO.106392-12-5) is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater.

TERGITOL XH Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse LD50 intravenous 129mg/kg (129mg/kg)   Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 569, 1993.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   Microvascular Research. Vol. 8, Pg. 320, 1974.
mouse LD50 intravenous 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse LD50 oral > 30300ug/kg (30.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
mouse LD50 oral 1830mg/kg (1830mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse LD50 oral 15gm/kg (15000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.
mouse LD50 subcutaneous 5500mg/kg (5500mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse LD50 unreported 400mg/kg (400mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 530mg/kg (530mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 750mg/kg (750mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 830mg/kg (830mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 1250mg/kg (1250mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 1400mg/kg (1400mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 2250mg/kg (2250mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 2700mg/kg (2700mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 3750mg/kg (3750mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported 4200mg/kg (4200mg/kg)   United States Patent Document. Vol. #4043344,
mouse LD50 unreported > 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4043344,
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Union Carbide Data Sheet. Vol. 7/14/1965,
rat LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES

BEHAVIORAL: ATAXIA		 National Technical Information Service. Vol. OTS0540972,
rat LD50 intraperitoneal 1140mg/kg (1140mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat LD50 oral > 30300ug/kg (30.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
rat LD50 oral 2300mg/kg (2300mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat LD50 oral 5gm/kg (5000mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 Wyandotte Chemicals Corporation Reports.
rat LD50 oral 5gm/kg (5000mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 Wyandotte Chemicals Corporation Reports.
rat LD50 oral 5gm/kg (5000mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Wyandotte Chemicals Corporation Reports.
rat LD50 oral 9380mg/kg (9380mg/kg)   "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 297, 1972.
rat LD50 oral 22400mg/kg (22400mg/kg)   Union Carbide Data Sheet. Vol. 7/14/1965,
rat LD50 subcutaneous 6900mg/kg (6900mg/kg)   Drugs in Japan Vol. 6, Pg. 797, 1982.

TERGITOL XH Safety Profile

Low toxicity by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.

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