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TES

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Name

TES

EINECS 230-906-3
CAS No. 7365-44-8 Density 1.554 g/cm3
PSA 135.47000 LogP -1.34880
Solubility H2O: 1 M at 20 °C, clear, colorless Melting Point ~223-225 °C
Formula C6H15NO6S Boiling Point N/A
Molecular Weight 229.254 Flash Point N/A
Transport Information N/A Appearance White crystalline powder
Safety 22-24/25-36-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 7365-44-8 (2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid) Hazard Symbols IrritantXi
Synonyms

Taurine,N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- (7CI,8CI);2-[[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]ethanesulfonicacid;2-[[Tris(hydroxymethyl)methyl]amino]ethanesulfonic acid;N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid;N-[Tris(hydroxymethyl)methyl]aminoethanesulfonic acid;TES;TES (bufferingagent);

Article Data 3

TES Synthetic route

107-04-0

1-Bromo-2-chloroethane

77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

Conditions
ConditionsYield
Stage #1: 1-Bromo-2-chloroethane; 2-amino-2-hydroxymethyl-1,3-propanediol With sodium hydroxide In water for 4h; pH=< 7.0; Reflux;
Stage #2: With copper; sodium sulfite In water for 16h; Reflux;
87%
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

27668-52-6

octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride

disodium 2-[[1-[[3-[dimethyl(octadecyl)ammonio]propyl-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfoethylamino)propoxy]-[3-hydroxy-2-(hydroxymethyl)-2-(2-sulfonatoethylamino)propoxy]silyl]oxymethyl]-2-hydroxy-1-(hydroxymethyl)ethyl]amino]ethanesulfonate chloride

Conditions
ConditionsYield
Stage #1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride In N,N-dimethyl-formamide at 145℃;
Stage #2: With sodium methylate In N,N-dimethyl-formamide
97%
112-77-6

(Z)-9-octadecenoyl chloride

7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

trioleate 2-[tris(oleoyloxymethyl)methylamino]-1-ethanesulfonic acid

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 65℃; for 3h; Large scale;77.8%
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

1-ethyl-3-methylimidazolium hydroxide

C6H11N2(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

75-59-2

tetramethyl ammoniumhydroxide

1421259-95-1

C4H12N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

77-98-5

tetraethylammonium hydroxide

1612259-34-3

C8H20N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

2052-49-5

tetra(n-butyl)ammonium hydroxide

1612259-35-4

C16H36N(1+)*C6H14NO6S(1-)

Conditions
ConditionsYield
In water at 20℃; for 12h;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

123-41-1

cholin hydroxide

cholinium 2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethane sulfonate

Conditions
ConditionsYield
In aq. buffer for 12h;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

TPO chloride

C29H35NO8PS(1-)*K(1+)

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;
7365-44-8

N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

(3,5-bis(chloromethyl)-2,4,6-trimethylphenyl)(diphenylphosphoryl)methanone

C36H49N2O14PS2(2-)*2K(1+)

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;

TES Specification

The TES, with the CAS registry number 7365-44-8, is also known as N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid. It belongs to the product categories of Biochemistry; Good's Buffers; Buffer. Its EINECS registry number is 230-906-3. This chemical's molecular formula is C6H15NO6S and molecular weight is 229.2514. Its IUPAC name is called 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]ethanesulfonic acid. The product should be sealed and stored in cool and dry place. TES is mainly used for the production of ph buffers for biological systems.

Physical properties of TES: (1)# of Rule of 5 Violations: 1; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 7; (7)#H bond donors: 5; (8)#Freely Rotating Bonds: 10; (9)Index of Refraction: 1.571; (10)Molar Refractivity: 48.442 cm3; (11)Molar Volume: 147.496 cm3; (12)Surface Tension: 82.13 dyne/cm; (13)Density: 1.554 g/cm3.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(CS(=O)(=O)O)NC(CO)(CO)CO
(2)InChI: InChI=1S/C6H15NO6S/c8-3-6(4-9,5-10)7-1-2-14(11,12)13/h7-10H,1-5H2,(H,11,12,13)
(3)InChIKey: JOCBASBOOFNAJA-UHFFFAOYSA-N

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