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Basic information

  • Name:

  • Albendazole

  • CAS No.:

  • 54965-21-8

  • Formula:
  • C12H15N3O2S
  • Synonyms:
  • Albendazole Bolus/tablet;O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate;Albendazole (CP/USP);Albenza (TN);Eskazole;Vermitan;(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester;Carbamic acid,[5-(propylthio)-1Hbenzimidazol- 2-yl]-,methyl ester;Methyl 5-(propylthio)-2-benzimidazolecarbamate;SKF-62979;Albendazole [USAN:BAN:INN:JAN];Albendazol [INN-Spanish];Bilutac;Carbamic acid, [5- (propylthio)-1H-benzimidazol-2-yl]-, methyl ester;Albenza;methyl N-(5-propylsulfanyl-3H-benzoimidazol-2-yl)carbamate;Zental;Albendazole (JAN/USP);((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French];Proftril;[5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester;SKF 62979;Prestwick_675;SKandF 62979;Zentel;Albendazole cp2005;

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Chemistry


IUPAC Name: Methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
Molecular Formula: C12H15N3O2S
Molecular Weight: 265.33
EINECS : 259-414-7
Product Category: Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries;Miscellaneous Compounds
Melting point: 208-210 °C
Storage tempreture: 0-6 °C
Index of Refraction: 1.634 
Molar Refractivity: 72.69 cm3
Molar Volume: 203.1 cm3
Surface Tension: 61.9 dyne/cm
Density of Albendazole (CAS NO.54965-21-8): 1.3 g/cm3

Uses

 Albendazole (CAS NO.54965-21-8) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. It is effective against: flatworms, flukes/trematodes, tapeworm/cestodes, echinococcosis, nematodes, hookworms, roundworms, whipworms, and threadworms or pinworms. In Africa, albendazole is being used to treat lymphatic filariasis as part of efforts to stop transmission of the disease. In Brazil and other countries it is used against giardiasis.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 99, 1995.
mouse LD50 oral 1500mg/kg (1500mg/kg)   Acta Leidensia. Vol. 57, Pg. 201, 1989.
rat LD50 intravenous 265mg/kg (265mg/kg)   Drugs in Japan Vol. -, Pg. 99, 1995.
rat LD50 oral 2400mg/kg (2400mg/kg)   Annales Pharmaceutiques Francaises. Vol. 40, Pg. 55, 1982.
women TDLo oral 256mg/kg/16D (256mg/kg) BLOOD: APLASTIC ANEMIA American Journal of Hematology. Vol. 53, Pg. 53, 1996.

Safety Profile

Hazard Codes: ToxicT
Risk Statements: 61-36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R61:May cause harm to the unborn child.
Safety Statements: 53-45-37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use. 
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany 2
RTECS FD1100000

Specification

 Albendazole , its cas register number is 54965-21-8. It also can be called Methyl 5-propylthio-2-benzimidazolecarbamate . It may cause dizziness, headache, fever, nausea, vomiting, or temporary hair loss. It is colourless crystalline solid.

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