94-36-0

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 36 (1985),p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 36 (1985),p. 267.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Community Right-To-Know List.

OSHA PEL: TWA 5 mg/m³
ACGIH TLV: TWA 5 mg/m³; Not Classifiable as a Human Carcinogen
DFG MAK: 5 mg/m³; Weak allergin and skin irritant
NIOSH REL: (Benzoyl Peroxide) TWA 5 mg/m³

For occupational chemical analysis use NIOSH: Benzoyl Peroxide, 5009.

The CAS registry number of Benzoyl peroxide is 94-36-0. The IUPAC name is benzoyl benzenecarboperoxoate. Its EINECS registry number is 202-327-6. In addition, the molecular formula is C₁₄H₁₀O₄ and the molecular weight is 242.23. It is a kind of white powder or crystals and belongs to the classes of Industrial/Fine Chemicals; Organic Peroxide; Synthetic Organic Chemistry.

Physical properties about Benzoyl peroxide are: (1)ACD/LogP: 2.859; (2)ACD/LogD (pH 5.5): 2.86; (3)ACD/LogD (pH 7.4): 2.86; (4)ACD/BCF (pH 5.5): 87.62; (5)ACD/BCF (pH 7.4): 87.62; (6)ACD/KOC (pH 5.5): 855.31 ; (7)ACD/KOC (pH 7.4): 855.31; (8)#H bond acceptors: 4; (9)#Freely Rotating Bonds: 5; (10)Index of Refraction:1.585; (11)Molar Refractivity: 64.737 cm³; (12)Molar Volume: 193.103 cm³; (13)Polarizability: 25.664 10-24cm³; (14)Surface Tension: 49.6240005493164 dyne/cm; (15)Density: 1.254 g/cm³; (16)Flash Point: 154.239 °C; (17)Enthalpy of Vaporization: 59.427 kJ/mol; (18)Boiling Point: 349.747 °C at 760 mmHg

Preparation of Benzoyl peroxide: firstly, prepare the material of sodium hydroxide and oxydol. Next, drop benzoyl chloride into mixture with stirring at reaction temperature below 0 °C. Then keep the temperature about 0 °C for 2-3 hours with stirring. By means of stalling layered and drying at low temperature you can get the product.

Uses of Benzoyl peroxide: it can be used to test formaldehyde and bravery sterol. And it can be used as quality improver of flour, intermediates of fine chemical products, additives of grain and oil, vulcanization agent of xylene silicone rubber and kyle F-rubber, catalyst of free radicals halogenating and radical sensitization reaction. In addition, it can react with piperidine to get 1-benzoyloxy-piperidine. This reaction will need reagent dipotassium hydrogen phosphate and solvent dimethylformamide. The reaction time is 21 hours by heating. The yield is about 60%.

When you are using this chemical, please be cautious about it as the following:
This chemical is explosive when dry. It may cause fire when contact with combustible material. And ti is irritating to eyes, respiratory system and skin and harmful in contact with skin and if swallowed. In addition, it has risk of impaired fertility. It is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Avoid exposure - obtain special instructions before use. It has refer to special instructions/safety data sheets. During using it, wear suitable protective clothing, gloves and eye/face protection. And keep away from combustible material. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.). In additon, this material and its container must be disposed of as hazardous waste and must be disposed of in a safe way. You shuld keep container tightly closed and avoid release to the environment.

You can still convert the following datas into molecular structure:
(1)SMILES: c1ccc(cc1)C(=O)OOC(=O)c2ccccc2
(2)InChI: InChI=1/C14H10O4/c15-13(11-7-3-1-4-8-11)17-18-14(16)12-9-5-2-6-10-12/h1-10H
(3)InChIKey: OMPJBNCRMGITSC-UHFFFAOYAV

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	skin	> 1gm/kg (1000mg/kg)		Kodak Company Reports. Vol. #900713,
mouse	LD50	intraperitoneal	250mg/kg (250mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
mouse	LD50	oral	5700mg/kg (5700mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967.
rat	LD50	oral	7710mg/kg (7710mg/kg)	LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	ARCO Chemical Company Report. Vol. JUN1982,