Reference

Hypoglycemic activity of amine derivatives

Hypoglycemic activity of amine derivatives. A possible mode of action. Polacek, I.; Ouart, J. (Chem. Fabrik, Heyden G.m.b.H, Regensburg, Ger.). Arzneim.-Forsch., 28(6), 984-9 (English) 1978. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Expts. were carried out to explain the hypoglycemic effect of dicyclohexylamine (DCH) [101-83-7] and related compds. The agents antagonized blood glucose increases in intact and hepatectomized rats infused with glucose, but not in intact rats receiving epinephrine, and induced liver glycogen rise in normal fasted but not in adrenalectomized rats. No effect on blood glucose of pancreatectomized dogs was found. DCH lowered blood triglycerides without influencing the concn. of plasma fatty acids. Intestinal absorption of glucose was not influenced by low concns. of the amines. Hypoglycemia may result, at least in part, from stimulated glucose transformation in the muscle tissue without an enhancement of anaerobic glycolysis.

Methods for determining the legal purity requirements for the sweetening agents saccharin, sodium saccharin, and sodium cyclamate

Methods for determining the legal purity requirements for the sweetening agents saccharin, sodium saccharin, and sodium cyclamate. Part II. Sodium cyclamate. Janssen, W.; Kreutzig, L.; Schulze, V.; Wolf, E. (Regensburg, Ger.). Dtsch. Apoth., 29(4), 174, 176, 178-9, 182, 184, 186, 188, 190 (German) 1977. CODEN: DAPOAG. ISSN: 0366-8622. DOCUMENT TYPE: Journal CA Section: 17 (Foods) Methods of testing Na cyclamate [139-05-9] for identity, loss on drying, heavy metals, Se, As, and cyclohexylamine [108-91-8], dicyclohexylamine [101-83-7], and aniline [62-53-3] are covered in detail. Cyclamate can be detd. by titrn. in nonaq. medium with HClO4 or by titrn. with NaNO2 with endpoint detection with KI-starch paper. Loss on drying (max. 1% allowed) is detd. by drying 3 h at 105°. Heavy metals (max. 10 mg/kg) are detd. by formation of sulfides in dil. acid solns. Se (max. 30 mg/kg) is detd. by ashing and colorimetry with 2,3-diaminonaphthalene. Colorimetry with Ag diethyldithiocarbamate after formation of AsH3 is used to det. As. Gas and thin-layer chromatog. methods are given for cyclohexylamine, dicyclohexylamine, and aniline (max. allowed 10, 1, and 1 mg/kg, resp.).