Detail of "108-65-6"

CAS Number:
108-65-6
Name:
2-Propanol, 1-methoxy-,2-acetate
Superlist Name:
1-Methoxy-2-propyl acetate
Molecular Structure:
Formula:
C₆H₁₂O₃
Molecular Weight:
132.1577
Deleted CAS:
142300-82-1
Synonyms:
2-Propanol,1-methoxy-, acetate (6CI,7CI,8CI,9CI);1-Methoxy-2-acetoxypropane;1-Methoxy-2-propanol acetate;2-Acetoxy-1-methoxypropane;2-Methoxy-1-methylethyl acetate;KR 20;NSC 2207;PGMEA;Propylene glycol 1-methyl ether 2-acetate;
EINECS:
203-603-9
Density:
0.959 g/cm³
Melting Point:
-87 °C
Boiling Point:
154.8 °C at 760 mmHg
Flash Point:
47.9 °C
Solubility:
19.8 g/L (25 °C) in water
Appearance:
colourless liquid
Hazard Symbols:
T,Xi
Risk Codes:
61-10-36
Safety:
53-25-45 Details
Transport Information:
UN 3271 3/PG 3

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Reference

Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies: Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies. Miller, R. R.; Hermann, E. A.; Young, J. T.; Calhoun, L. L.; Kastl, P. E. (Toxicol. Res. Lab., Dow Chem. USA, Midland, MI 48640, USA). Toxicol. Appl. Pharmacol., 75(3), 521-30 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Male rats were given a single oral dose of ~8.7 mmol/kg of 1-14C-labeled PGMEA [108-65-6] or exposed to 3000 ppm [1-14C]PGMEA for 6 h. After dosing, expired air, excreta, and tissues were analyzed for 14C activity, and metabolites in urine were isolated and identified. Approx. 64% of the administered 14C activity was eliminated as 14CO2 and ~24% was excreted in urine within 48 h after a single oral dose of radiolabeled PGMEA. Similarly, 53% was eliminated as 14CO2 and 26% was excreted in urine within 48 h after the inhalation exposure. Propylene glycol [57-55-6], propylene glycol monomethyl ether (PGME) [1320-67-8], and the PGME sulfate [85684-22-6] and PGME glucuronide [85684-23-7] were identified as urinary metabolites after oral dosing, as well as after inhalation exposure to PGMEA. The urinary metabolite profile and disposition of [14C]PGMEA were nearly identical to results previously obtained with PGME, indicating that PGMEA is rapidly and extensively hydrolyzed to PGME in vivo. A short-term vapor inhalation toxicity study in which male and female rats and mice were exposed to 0, 300, 1000, or 3000 ppm PGMEA confirmed that there were no substantial differences in the systemic effects of PGMEA as compared to PGME. However, histopathol. examn. did reveal changes in the olfactory portions of the nasal mucosa of rats and mice exposed to PGMEA, which may be related to HOAc resulting from hydrolysis of PGMEA in the nasal epithelium.

Detection method for identifying hydrolases: Detection method for identifying hydrolases. Bornscheuer, Uwe T.; Baumann, Marcus (BASF Aktiengesellschaft, Germany). PCT Int. Appl. WO 2002094949 A2 28 Nov 2002, 24 pp. DESIGNATED STATES: W: US; RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR. (German). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C09D005-03. APPLICATION: WO 2002-EP5570 21 May 2002. 108-65-6 and 27999-96-8 which are cas registry numbers of chemicals are mentioned. PRIORITY: DE 2001-10124799 21 May 2001. DOCUMENT TYPE: Patent CA Section: 80 (Organic Analytical Chemistry) A detection method for identifying hydrolases is presented, based on the optical detection of released acetic acid.Except for chemicals metioned above, 64-19-7 is also used. The inventive method is particularly suitable for High Throughput Screening (HTS) of prokaryotic or eucaryotic samples. The invention also relates to test kits to implement the above method; a method for the isolation of hydrolases having a modified property profile, for example improved enantioselectivity, by using the detection method. ..

Detail of "108-65-6"

2-Propanol, 1-methoxy-,2-acetate

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CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

CAS No.108-65-6 1-Methoxy-2-propyl acetate

Reference