Reference

Structure activity relationship of antitumor palladium complexes

Structure activity relationship of antitumor palladium complexes. Gill, Devinder (Dep. Biol. Sci., Carnegie-Mellon Univ., Pittsburgh, PA 15213, USA). Dev. Oncol., 17(Platinum Coord. Complexes Cancer Chemother.), 267-78 (English) 1984. CODEN: DEOND5. ISSN: 0167-4927. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Antitumor Pd complexes were prepd. by the reaction of Na tetrachloro-Pd (II) with cis- [1436-59-5] and trans-1,2-diaminocyclohexane [1121-22-8] or other suitable amino salts. 89420-26-8 and 89420-27-9 are also in the experiment. The hydroxy-bridged oligomeric diaminocyclohexane-Pd, and the nitrate- and tartronato-forms of all of the Pd complexes were also prepd. The antitumor activity of the compds. was assessed in mice bearing ascitic sarcoma-180 J cells. The dinitrate complexes and the hydroxo-bridged oligomers of bidentate amines were as potent antitumor agents as cisplatin. Complexes having monodentate amines and monodentate leaving group were inactive. Other structure-antitumor activity relationships of the Pd compds are discussed at length. .

Bis-platinum complexes as antitumor agents

Bis-platinum complexes as antitumor agents. Andrulis, Peter J., Jr.; Schwartz, Paul (Andrulis Research Corp., USA). PCT Int. Appl. WO 8404524 A1 22 Nov 1984, 40 pp. DESIGNATED STATES: W: AU, BR, DK, FI, JP, NO. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: C07F015-00; A01N055-02; A61K031-28. APPLICATION: WO 84-US706 10 May 1984. PRIORITY: US 83-493177 10 May 1983. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 25 Bis-Pt complexes [I, A = ligand contg. a carboxylate, phenolate, sulfonate, or phosphonate group, Z = a water-solubilizing group, n = 0 or a pos. integer with the proviso that n = 0 only when at least 1 of the Pt-coordinating acidic groups is sulfonate or phosphonate or when at least 1 Pt ion is a Pt(IV) ion; and R1, R2, R3, R4, R5 and R6 = H, C1-20 alkyl, aryl, aralkyl or alkaryl group or together form 1 or more C1-30 alkylene, cycloalkylene, arylene, aralkylene or alkarylene groups] are useful as water-sol. antitumor agents. Thus, K hexachloroplatinate (IV) was prepd. from chloroplatinic acid and Pt and reduced with N2H4-HCl to give the K tetrachloro platinate. This was then treated with a mixt. of cis-1,2-diaminocyclohexane [1436-59-5] and trans-isomer [1121-22-8] to give a mixt. of cis-dichloro-(1,2-diaminocyclohexane)platinum [61848-70-2] and trans-isomer [38780-40-4]. Subsequent treatment of this mixt. with benzenepentacarboxylic acid [1585-40-6] gave a mixt. of cis-benzenepentacarboxylatobis[(1,2-diaminocyclohexane)platinum(II) and its trans isomer.