Reference

Penicillin compositions

Penicillin compositions. Hubbard, Ann Frances (Beecham Group Ltd., Engl.). Brit. GB 1477672 22 Jun 1977, 3 pp., Addn. to Brit. 1,476,432. (English). (United Kingdom). CODEN: BRXXAA. CLASS: IC: A61K031-43. APPLICATION: GB 74-8147 22 Feb 1974. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 Bactericidal compns. were prepd. by adding 100 mL H2O to an intimate blend of 5.000 g carbenicillin Na salt [4800-94-6] or ticarcillin Na salt with one of the following: 0.100 g NH4Cl [12125-02-9], 0.461 g N-methyl-1-D-glucamine.HCl [35564-86-4], 0.383 g L-lysine.HCl [10098-89-2], 0.313 g Tris.HCl [1185-53-1], or 0.502 g glucosamine.HCl [66-84-2]. The inclusion of the acid addn. salt reduces the risk of hypokalemia during treatment and produces a prolonged high blood level of the penicillin.

Pharmaceutical compositions containing penicillin salts

Pharmaceutical compositions containing penicillin salts. Hubbard, Ann Frances (Beecham Group Ltd., Engl.). Brit. GB 1476432 16 Jun 1977, 3 pp., Addn. to Brit. 1,312,891. (English). (United Kingdom). CODEN: BRXXAA. CLASS: IC: A61K031-43. APPLICATION: GB 73-56602 6 Dec 1973. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 Bactericidal compns. were prepd. by adding 100 mL H2O to an intimate blend of 5.000 g carbenicillin Na K salt [24390-13-4] or ticarcillin Na K salt [64691-58-3] with one of the following: 0.100 g NH4Cl [12125-02-9], 0.461 g N-methyl-1-D-glucamine.HCl [35564-86-4], 0.383 g L-lysine.HCl [10098-89-2], 0.313 g (HOCH2)3CNH2.HCl [1185-53-1], or 0.502 g glucosamine.HCl [66-84-2]. The inclusion of the acid addn. salt reduces the risk of hypokalemia during treatment.