Detail of "124-30-1"

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CAS Number:
124-30-1
Name:
Octadecanamine
Molecular Structure:
Formula:
C₁₈H₃₉N
Molecular Weight:
269.52 .
Deleted CAS:
1341-47-5|258339-97-8|457883-16-8|8038-60-6
Synonyms:
Armeen 18;Armeen 18D;Armeen 18D-FLK;Armofilm;Farmin 80;Genamin SH 100;Kemamine P 990D;Monooctadecylamine;NSC 9857;Nissan Amine AB;ODA;Stearamine;Stearylamine;n-Octadecylamine;n-Stearylamine;1-Aminooctadecane;1-Octadecylamine;Adogenen 142;Alamine 7;Alamine7D;Amine 18D;Amine AB;
EINECS:
204-695-3
Density:
0.818 g/cm³
Melting Point:
50-60 °C
Boiling Point:
348.875 °C at 760 mmHg
Flash Point:
154.077 °C
Solubility:
practically insoluble in water
Appearance:
white solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38-41-38
Safety:
26-36-37/39-28B Details
Transport Information:
UN 3259

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Reference

Preparation and characterization of doxorubicin-containing liposomes: Preparation and characterization of doxorubicin-containing liposomes. II. Loading capacity, long-term stability and doxorubicin-bilayer interaction mechanism. Crommelin, D. J. A.; Van Bloois, L. (Subfac. Pharm., Univ. Utrecht, Utrecht 3511 GH, Neth.). Int. J. Pharm., 17(2-3), 135-44 (English) 1983. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Doxorubicin (I) [23214-92-8] loading capacity was detd. for neg. (phosphatidylcholine-cholesterol [57-88-5]-phosphatidylserine, :1) and pos. (phosphatidylcholine-cholesterol-stearylamine [124-30-1] :3) liposomes prepd. according to the film method with I added to the phospholipids before film formation. I assocn. depended on the initial ratio of I/phospholipid, the charge and the size. The max. loading capacity was 60-75 mmol I/mol phospholipid for the neg. and ~55 mmol I/mol phospholipid for pos., nonfiltered, multilamellar liposomes. Filtration or ultrasonication/ultracentrifugation reduced the I-bilayer interaction.Several substances with their cas registry numbers 57-88-5 and 23214-92-8 may be metioned in this study. Loss on storage of I from the filtered, multilamellar, or unilamellar vesicles decreased in the following order: filtered neg. < unilamellar pos. < unilamellar neg. vesicles. Pos. unilamellar vesicles increased in particle size on storage. Neg. liposomes were stable. z-Potentials of pos. or neg. liposomes did not depend on the presence of assocd. I. This makes a purely electrostatic mechanism of interaction between the drug and the bilayer unlikely. If I was added to the phospholipid film in the hydration buffer a dramatic drop in I-bilayer assocd. was obsd. for pos. liposomes. For neg. liposomes the loading efficiency was unaffected. .

Vaccines against diseases causing bacteria with capsular polysaccharides: Vaccines against diseases causing bacteria with capsular polysaccharides. Snippe, Harm; Willers, Johannes Marius Nicolaas; Van Houte, Arend Jan; Vliegenthart, Johannes Frederik G.; Kamerling, Johannis Paulus; Van Dam, Jan Evert Gerard (Rijksuniversiteit Utrecht, Neth.). Eur. Pat. Appl. EP 97407 A1 4 Jan 1984, 12 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K039-02. APPLICATION: EP 83-200929 22 Jun 1983.Several substances with their cas registry numbers 63-89-8 and 124-30-1 may be metioned in this study. PRIORITY: NL 82-2527 22 Jun 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Vaccines against pathogenic bacteria with capsular polysaccharides contain suitable oligosaccharides anchored in a liposome via amines. The capsular polysaccharides are hydrolyzed to oligosaccharides with 6-10 monosaccharide units. Streptococcus pneumoniae Type III was cultivated for 4 days, the cells were recovered, neutralized and an impure capsular polysaccharide obtained was washed. Dissolving in water followed by purifn. with HCl, EtOH and water and freeze-drying yielded a pure capsular polysaccharide. This polysaccharide was hydrolyzed with H2SO4 and the resulting soln. was neutralized with BaSO4, and centrifuged. The supernatant was freeze-dried, the resulting oligosaccharides were purified by Sephadex chromatog. The oligosaccharides had a high affinity against antibodies. Liposome encapsulation of the oligosaccharides is described. .

Detail of "124-30-1"

Octadecanamine

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