Reference

Antileishmanial activity of liposome-encapsulated meglumine antimonate in the dog

Antileishmanial activity of liposome-encapsulated meglumine antimonate in the dog. Chapman, W. L., Jr.; Hanson, W. L.; Alving, C. R.; Hendricks, L. D. (Dep. Pathol., Univ. Georgia, Athens, GA 30602, USA). Am. J. Vet. Res., 45(5), 1028-30 (English) 1984. CODEN: AJVRAH. ISSN: 0002-9645. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Each dog was inoculated i.v. with 1.0 ′ 108 amastigotes of a Khartoum strain of Leishmania donovani/kg of body wt. The antileishmanial agents [liposome-encapsulated meglumine antimonate (I)(LEMA) [133-51-7] or unencapsulated I] were given once daily, i.v., for 1, 4, or 10 consecutive days beginning the 12th day after inoculation. A single injection of LEMA (0.61 mg Sb/kg body wt.) resulted in 89% suppression and 4 consecutive daily injections of LEMA (1.94 mg Sb/kg/day) resulted in 95.8% suppression of splenic parasites. The dose of LEMA that would give 50% suppression (SD50) was approx. 0.029 mg Sb/kg. The SD50 for unencapsulated drug was approx. 24 mg Sb/kg. The liposome-encapsulated drug was estd. to be >700-fold as effective as the unencapsulated drug. Liposomes can markedly reduce the drug dosage required for treatment of visceral leishmaniasis in dogs.

Toxicity and efficacy of the antileishmanial drug meglumine antimoniate in the owl monkey (Aotus trivirgatus)

Toxicity and efficacy of the antileishmanial drug meglumine antimoniate in the owl monkey (Aotus trivirgatus). Chapman, W. L., Jr.; Hanson, W. L.; Hendricks, L. D. (Coll. Vet. Med., Univ. Georgia, Athens, GA 30602, USA). J. Parasitol., 69(6), 1176-7 (English) 1983. CODEN: JOPAA2. ISSN: 0022-3395. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Owl monkeys infested with Leishmania donovai were given meglumine antimoniate (I) [133-51-7] (6.25-500 mg Sb/kg/day, i.m.) for 10 consecutive days beginning 10 days post inoculation. I was toxic to the owl monkey at >125 mg/kg/day and I was effective therapeutically against L. donovani at dosages of 15.625-125 mg/kg/day.