Reference

Behavioral effects of intrahippocampal injections of clonidine, yohimbine and salbutamol in the rat

Behavioral effects of intrahippocampal injections of clonidine, yohimbine and salbutamol in the rat. Verleye, Marc; Bernet, Francois (Lab. Neurophysiol.In this study， 4205-90-7 and 18559-94-9 are also used. Neurobiol., Univ. Sci. Tech. Lille, Villeneuve d'Ascq F 59655, Fr.). Pharmacol., Biochem. Behav., 26(2), 421-4 (English) 1987. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Intrahippocampal injections of adrenergic drugs, clonidine [4205-90-7] (a2-agonist), yohimbine [146-48-5] (an a2-antagonist), and salbutamol [18559-94-9] (a b2-agonist) were performed in the awake rat. The injection of a high dose of clonidine caused a depression in locomotion in the open-field. Yohimbine partially antagonized the clonidine-induced hypomotility. The intrahippocampal injection of salbutamol had no effect on ambulatory behavior of the rat. These results suggest that the role played by the anterodorsal hippocampus in modifying behavior in novel situations is dependent on the specific subpopulation of adrenoceptors that is stimulated. .

The effects of some a-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine

The effects of some a-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Rhodes, K. F.; Waterfall, J. F. (Wyeth Res., Maidenhead SL6 0PH, UK). Naunyn-Schmiedeberg's Arch. Pharmacol., 335(3), 261-8 (English) 1987. CODEN: NSAPCC. ISSN: 0028-1298. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The benzoquinolizines Wy 25309 [82059-40-3], Wy 26703 [87201-33-0], and Wy 27127 [95669-35-5], previously reported as potent antagonists at presynaptic a2-adrenoceptors were also potent antagonists of B-HT 933 [36067-72-8] in isolated saphenous veins of the dog, confirming their activity at post synaptic a2-adrenoceptors. 131-03-3 and 59803-99-5 which are cas registry numbers are also used here. Yohimbine [146-48-5] was a more potent antagonist of B-HT 8933 in isolated saphenous vein than were the Wy compds. or idazoxan [79944-58-4], contrasting with the reported potencies of these compds. at presynaptic sites in rat vas deferens and raising the possibility of differences between pre- and postsynaptic a2-adrenoceptors. Contractions of the saphenous vein were obsd. with high concns. of idazoxan. The pA2 values for the group of a2-adrenoceptor antagonists on the canine saphenous vein against B-HT 933 and UK-14304 tartrate [59803-99-5] suggest an interaction with a2- rather than a1-adrenoceptors. However, yohimbine and rauwolscine [131-03-3] were more potent, and idazoxan and Wy 27127 less potent, antagonists of B-HT 933 than would have been expected from previous studies on the rat vas deferens, raising the possibility of differences between pre- and postsynaptic a2-adrenoceptors. There was evidence for a modification of the antagonism of B-HT 933 by a2-adrenoceptor antagonists in the presence of desipramine and corticosterone. The high pA2 values for the a2-adrenoceptor-selective antagonists against methoxamine [390-28-3] would suggest an interaction with both a1- and a2-adrenoceptors in canine saphenous vein, though the a1-selective antagonists indoramin and prazosin had pA2 values consistent with an action at a1-sites. .