Detail of "14721-66-5"

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Phytol derived compounds in the geosphere

Phytol derived compounds in the geosphere. De Leeuw, J. W.; Simoneit, B. R.; Boon, Jaap J.; Rijpstra, W. Irene C.; De Lange, Frits; Van der Leeden, J. C. W.; Correia, V. A.; Burlingame, A. L.; Schenck, P. A. (Dep. Chem. Chem. Eng.Several reagents such as 150-86-7 is used here., Delft Univ. Technol., Delft, Neth.). Adv. Org. Geochem., Proc. Int. Meet., 7th, Meeting Date 1975, 61-79. Edited by: Campos, R.; Goni, J. Empresa Nac. Adaro Invest. Mineras, SA: Madrid, Spain. (English) 1977. CODEN: 38TKAK. DOCUMENT TYPE: Conference CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Section cross-reference(s): 30, 53 Keeping phytol [150-86-7] and montmorillonite under air or in vacuo at 20° or 60° gave mixts. of isoprenoid hydrocarbons, ketones, aldehydes, acids, and alcs., together with a no. of dimers and trimers. Incubation of 7R,11R-phytol labeled with carbon-14 [67669-05-0] with a lake sediment gave mixed phytadienes, hexahydrofarnesylacetone [502-69-2], phytanic acid [14721-66-5], and a dimer. In some recent sediments there were detected phytol isomers and isoprenoid ketones and acids, e.g., phytenic acid [3653-46-1]. The occurrence of the phytol derivs. is discussed in relation to early diagenetic processes in sediments. .

Phytanic acid activation in rat liver peroxisomes is catalyzed by long-chain acyl-CoA synthetase

Phytanic acid activation in rat liver peroxisomes is catalyzed by long-chain acyl-CoA synthetase. Watkins, P. A.Several substances are used for example 14721-66-5 and 9013-18-7 which are their cas registry numbers.; Howard, A. E.; Gould, S. J.; Avigan, J.; Mikhalik, S. J. ( Kennedy Krieger Research Inst., Johns Hopkins Univ. School Medicine, Baltimore, MD 21205, USA). Journal of Lipid Research, 37(11), 2288-2295 (English) 1996 Lipid Research, Inc. CODEN: JLPRAW. ISSN: 0022-2275. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) In Refsum disease, disorders of peroxisome biogenesis, and rhizomelic chondrodysplasia punctata, pathol. accumulation of phytanic acid results from impaired a-oxidn. of this branched-chain fatty acid. Previous studies from this lab. indicated that activation of phytanic acid to its CoA deriv. precedes its a-oxidn. in peroxisomes. It was reported that this reaction is catalyzed by a unique phytanoyl-CoA synthetase in human peroxisomes. We wanted to det. whether phytanic acid activation in rats required long-chain acyl-CoA synthetase (LCS), very long-chain acyl-CoA synthetase (VLCS), or a different enzyme. To test directly whether LCS could activate phytanic acid, rat liver cDNA encoding this enzyme was transcribed and translated in vitro. The expressed enzyme had both LCS activity (assayed with palmitic acid, C) and phytanoyl-CoA synthetase activity; VLCS activity (assayed with lignoceric acid, C) was not detectable. The ratio of phytanoyl-CoA synthetase activity to palmitoyl-CoA synthetase activity for LCS synthesized in vitro (~20%) was higher than that obsd. in peroxisomes isolated from rat liver (5-10%), suggesting that the expressed enzyme contained sufficient phytanoyl-CoA synthetase activity to account for all activity obsd. in intact peroxisomes. Further expts. were carried out to verify that phytanic acid was activated by LCS in rat liver peroxisomes. Attempts to sep. LCS from phytanoyl-CoA synthetase by chromatog. on several matrixes were unsuccessful. Preparative isoelec. focusing revealed that phytanoyl-CoA synthetase and LCS had indistinguishable isoelec. points. Phytanoyl-CoA synthetase activity was inhibited by unlabeled palmitic acid but not by lignoceric acid. Heat treatment inactivated both phytanoyl-CoA and palmitoyl-CoA synthetase activities at similar rates. 5,8,11,14-Eicosatetraynoic acid inhibited activation of phytanic acid and palmitic acid in a parallel dose-dependent manner, whereas activation of lignoceric acid was not affected. These data support our conclusion that rat liver LCS, an enzyme known to be present in peroxisomal membranes, has phytanoyl-CoA synthetase activity. .