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CAS No.: | 2133-40-6 |
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Name: | Methyl L-prolinate hydrochloride |
Article Data: | 134 |
Molecular Structure: | |
Formula: | C6H12ClNO2 |
Molecular Weight: | 165.62 |
Synonyms: | L-Proline,methyl ester, hydrochloride (9CI);Proline, methyl ester, hydrochloride, L-(6CI,7CI,8CI);(2S)-(Methoxycarbonyl)pyrrolidine hydrochloride;(S)-Methylpyrrolidine-2-carboxylate hydrochloride;(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride;L-Proline methyl ester monohydrochloride;Methyl proline hydrochloride;H-Pro-OMe.HCl;H-Pro-OMe·HCl;L-Proline, methylester, hydrochloride (1:1); |
EINECS: | 218-363-0 |
Density: | 1.055 g/cm3 |
Melting Point: | 69-71 °C(lit.) |
Boiling Point: | 169.9 °C at 760 mmHg |
Flash Point: | 56.5 °C |
Appearance: | crystalline |
Hazard Symbols: | Xi |
Risk Codes: | 36/38 |
Safety: | 26-37/39 |
PSA: | 38.33000 |
LogP: | 1.04220 |
Conditions | Yield |
---|---|
With thionyl chloride for 1.5h; Heating; | 100% |
With hydrogenchloride for 4h; Ambient temperature; | 100% |
With thionyl chloride for 1.5h; Heating; | 100% |
Conditions | Yield |
---|---|
With thionyl chloride In methanol at 20℃; | 100% |
With sulfuryl dichloride; trimethyl orthoformate In methanol | |
With sulfuryl dichloride; trimethyl orthoformate In methanol | |
With sulfuryl dichloride; trimethyl orthoformate In methanol |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol; ethyl acetate at 80℃; under 750.075 Torr; | 99% |
(S)-N-(tert-butoxycarbonyl)proline methyl ester
L-proline methyl ester monohydrochloride
Conditions | Yield |
---|---|
With aluminium chloride doped on a neutral alumina for 0.0166667h; Irradiation; | 88% |
With thionyl chloride In methanol at 0 - 75℃; for 1.5h; | 86% |
With hydrogenchloride In ethyl acetate at 15℃; for 2h; |
methanol
1-(tert-butoxycarbonyl)-L-proline
L-proline methyl ester monohydrochloride
Conditions | Yield |
---|---|
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Inert atmosphere; Cooling with ice; Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h; Inert atmosphere; | 88% |
Stage #1: methanol; 1-(tert-butoxycarbonyl)-L-proline With thionyl chloride at 70℃; for 7.5h; Cooling with ice; Stage #2: With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 0.0833333h; | 88% |
Conditions | Yield |
---|---|
With thionyl chloride Ambient temperature; |
Conditions | Yield |
---|---|
Stage #1: L-proline With thionyl chloride Stage #2: methyl iodide |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: SOCl2 View Scheme |
Conditions | Yield |
---|---|
With hydrogenchloride In water |
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The Molecular Structure of L-Proline methyl ester hydrochloride (CAS NO.2133-40-6):
Empirical Formula: C6H12ClNO2
Molecular Weight: 165.618
IUPAC Name: methyl pyrrolidine-2-carboxylate hydrochloride
Appearance: Crystalline
Nominal Mass: 165 Da
Average Mass: 165.618 Da
Monoisotopic Mass: 165.055656 Da
Flash Point: 56.5 °C
Melting Point: 69-71 °C
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 169.9 °C at 760 mmHg
Vapour Pressure: 1.51 mmHg at 25°C
Synonyms: H-l-pro-ome hcl ; H-pro-ome hcl ; Methyl l-prolinate hydrochloride ; L-pyrrolidine-2-carboxylic acid methyl ester hcl ; L-proline methyl ester hydrochloride ; L-proline methyl ester hydrochloride salt ; Proline-ome hcl ; L-proline methyl ester hcl
Product Categories: AMINOACIDS DERIVATIVES;Esters;Pyrrolidines;Amino Acid Derivatives;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amino hydrochloride;Peptide Synthesis;Amino Acid Derivatives;Proline
Hazard Codes: Xi
Risk Statements: 36/38
R36/38: Irritating to eyes and skin
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
F: 3-8-10-21
Hazard Note: Harmful
Conditions to Avoid: Incompatible materials, dust generation, excess HEAT, exposure to moist air or WATER.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Hydrogen chloride, NITROGEN oxides, CARBON monoxide, irritating and toxic fumes and gases, CARBON dioxide.
Hazardous Polymerization: Has not been reported