Detail of "2133-40-6"

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CAS Number:
2133-40-6
Name:
Methyl L-prolinate hydrochloride
Molecular Structure:
Formula:
C₆H₁₂ClNO₂
Molecular Weight:
165.62
Synonyms:
L-Proline,methyl ester, hydrochloride (9CI);Proline, methyl ester, hydrochloride, L-(6CI,7CI,8CI);(2S)-(Methoxycarbonyl)pyrrolidine hydrochloride;(S)-Methylpyrrolidine-2-carboxylate hydrochloride;(S)-Pyrrolidine-2-carboxylic acid methyl ester hydrochloride;L-Proline methyl ester monohydrochloride;Methyl proline hydrochloride;H-Pro-OMe.HCl;H-Pro-OMe·HCl;L-Proline, methylester, hydrochloride (1:1);
EINECS:
218-363-0
Density:
1.055 g/cm³
Melting Point:
69-71 °C(lit.)
Boiling Point:
169.9 °C at 760 mmHg
Flash Point:
56.5 °C
Appearance:
crystalline
Hazard Symbols:
Xi
Risk Codes:
36/38
Safety:
26-37/39 Details

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Reference

Solution synthesis of the glyco-hexapeptide sequence of the human oncofetal fibronectin defined by monoclonal antibody FDC-6: Solution synthesis of the glyco-hexapeptide sequence of the human oncofetal fibronectin defined by monoclonal antibody FDC-6. Gobbo, M.; Biondi, L.; Filira, F.; Rocchi, Raniero (Biopolym. Res. Cent., Univ. Padova, Padua 35131, Italy). Int. J. Pept. Protein Res., 38(5), 417-27 (English) 1991. CODEN: IJPPC3. ISSN: 0367-8377. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 15 The glycohexapeptide sequence H-Val-Thr(R)-His-Pro-Gly-Tyr-OH (R = 2-acetamido-2-deoxy-a-D-galactopyranosyl) was synthesized in soln. by the segment condensation procedure and the stepwise procedure. A peracetylated, O-galactosaminyl threonine deriv. was used for incorporating the glycosylated amino acid residue into the peptide chain. A consistent racemization occurred during the acylation of H-His-Pro-Gly-Tyr(OCH2Ph)-OCH2Ph with protected N-terminal dipeptide using the 1-benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate-1-hydroxybenzotriazole (BOP-HOBt) procedure, and the D-allothreonine contg. glycohexapeptide was isolated in about 20% yield.There are some commonly used reagents with their cas registry numbers 2133-40-6 and 76912-67-9 in this article. Stepwise elongation of the C-terminal tetrapeptide in the presence of the same coupling reagents yielded the L-threonine contg. diastereoisomer without detectable racemization. A side product, the Nim-ethoxycarbonylated hexapeptide deriv., formed during the EEDQ-mediated condensation of with the C-terminal tetrapeptide, was isolated and characterized. Preliminary studies showed that the synthetic glycohexapeptide is a good competitive inhibitor of the binding of the FDC-6 monoclonal antibody to the oncofetal fibronectin, supporting the idea that it should represent the min. essential structure required for the FDC-6 activity. .

Asymmetric synthesis of (1R,8S)- and (1S,8S)-1-hydroxypyrrolizidin-3-ones via the aldol reaction between N-Boc-(S)-prolinal and chiral acetate enolate equivalents derived from (S)- and (R)-[(h5-C5H5)Fe(CO)(PPh3)COCH3]: Asymmetric synthesis of (1R,8S)- and (1S,8S)-1-hydroxypyrrolizidin-3-ones via the aldol reaction between N-Boc-(S)-prolinal and chiral acetate enolate equivalents derived from (S)- and (R)-[(h5-C5H5)Fe(CO)(PPh3)COCH3]. Beckett, R. Paul; Davies, Stephen G.; Mortlock, Andrew A. (Dyson Perrins Lab., Oxford OX1 3QY, UK). Tetrahedron: Asymmetry, 3(1), 123-36 (English) 1992. CODEN: TASYE3. ISSN: 0957-4166. 2133-40-6 and 12101-02-9 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 27, 29, 31 The synthesis of title pyrrolizidinones I and II has been achieved with excellent stereocontrol using chiral acetate enolate equiv. derived from the iron acetyl complex [(h5-C5H5)Fe(CO)(PPh3)COCH3]. The different diastereoselectivities in the two syntheses are rationalized in terms of the concept of double asym. induction and the transition state models for the aldol reactions of such enolates are discussed. .

Detail of "2133-40-6"

Methyl L-prolinate hydrochloride

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CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

CAS No.2133-40-6 Methyl L-prolinate hydrochloride

Reference