CAS No.152-11-4,(+/-)-Verapamil hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	152-11-4
Name:	(+/-)-Verapamil hydrochloride
Article Data:	8

Formula:	C₂₇H₃₈N₂O₄.HCl
Molecular Weight:	491.071
Synonyms:	Benzeneacetonitrile,a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-,monohydrochloride (9CI);Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-,monohydrochloride (8CI);Akilen;Anpec;Apoacor;Arapamyl;Berkatens;Calan SR;Calaptin 240SR;Calaptin 80;Cardiabeltin;Civicor Retard;Cordilox;Dignover;Dilacoran HTA;Finoptin;
EINECS:	205-800-5
Density:	1.058g/cm3
Melting Point:	142 °C (dec.)(lit.)
Boiling Point:	586.1 °C at 760 mmHg
Flash Point:	308.3 °C
Solubility:	water: >30 mg/mL
Appearance:	white to off-white powder
Hazard Symbols:	T
Risk Codes:	25-23/24/25
Safety:	45-36/37/39-36/37
Transport Information:	UN 2811 6.1/PG 3
PSA:	63.95000
LogP:	5.89508

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Chemistry

Product Name: Verapamil hydrochloride (CAS NO.152-11-4)

IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
Molecular Formula: C₂₇H₃₉ClN₂O₄
Molecular Weight: 491.062560 g/mol
Appearance: odorless white solid
Melting Point: 142 °C (dec.)(lit.)
Boiling Point: 586.1 °C at 760 mmHg
Flash Point: 308.3 °C
Water solubility: >30 mg/mL
Merck: 13,10012
EINECS: 205-800-5
Product Categories: Miscellaneous Biochemicals; Organics; Calcium channel

Uses

Verapamil hydrochloride (CAS NO.152-11-4) is primarily for the treatment of paroxysmal supraventricular tachycardia, also used the treatment of angina, hypertension, and hypertrophic cardiomyopathy infarction.

Toxicity Data With Reference

1.	cyt-hmn:lyms 30 µmol/L	MUREAV Mutation Research. 244 (1990),135.
2.	orl-man TDLo:26 mg/kg:CVS,PUL	HUTODJ Human Toxicology. 4 (1985),327.
3.	orl-man TDLo:143 µg/kg/4H-C:CVS	ICMED9 Intensive Care Medicine. 8 (1982),55.
4.	ivn-man LDLo:256 µg/kg/1H-I:CVS	AEMED3 Annals of Emergency Medicine. 14 (1985),159.
5.	ivn-man TDLo:71 µg/kg/5M-C	SMJOAV Southern Medical Journal. 75 (1982),1429.
6.	orl-wmn TDLo:135 mg/kg:EYE,PUL	AJCDAG American Journal of Cardiology. 58 (1986),1142.
7.	ivn-wmn TDLo:200 µg/kg/15S-C:CVS,PUL	NYSJAM New York State Journal of Medicine. 83 (1983),1181.
8.	orl-inf TDLo:80 mg/kg	PEDIAU Pediatrics. 73 (1984),543.
9.	ivn-inf TDLo:1026 µg/kg:CVS	ADCHAK Archives of Disease in Childhood. 58 (1983),465.
10.	orl-rat LD50:108 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),766.

Safety Profile

Safety Information of Verapamil hydrochloride (CAS NO.152-11-4):
Hazard Codes:T
Risk Statements:25-23/24/25
Safety Statements:45-36/37/39-36/37
RIDADR:UN 2811 6.1/PG 3
WGK Germany:3
RTECS:YV8320000
F:8-10
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects; arrhythmias, cardiomyopathy, coma, cyanosis, dyspnea, fall in blood pressure, mydriasis, pulse rate decrease. Human reproductive effects: impotence. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x and HCl.

Specification

Verapamil hydrochloride , its CAS NO. is 152-11-4, the synonyms are (+/-)-Verapamil hydrochloride ; 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-valeronitril ; Cordilox ; Finoptin ; Iproveratrilhydrochloride ; Izoptinhydrochloride .