Reference

Effects of some drugs on doxepin toxicity in mice

Effects of some drugs on doxepin toxicity in mice. Elonen, E.; Mattila, M. J. (Dep. Pharmacol., Univ. Helsinki, Helsinki, Finland). Proc. Eur. Soc. Toxicol., 17(Predict. Chronic Toxic. Short Term Stud., Proc. Meet., 1975), 383-90 (English) 1976. CODEN: PESTD5.Several substances with their cas registry numbers 318-98-9 and 11140-85-5 may be metioned in this study. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Clonidine-HCl [4205-91-8] and NaHCO3, as compared to other drugs tested, produced lower mortality when given to mice that had been injected i.p. with doxepin-HCl (I-HCl) [1229-29-4]. Na phenytoin [630-93-3] and propranolol-HCl [318-98-9] in large doses increased the I toxicity. Neostigmine methylsulfate [51-60-5], glucagon-HCl [11140-85-5], verapamil-HCl [152-11-4], and Ca were without effect. The pretreatment with physostigmine salicylate [57-64-7], or atropine sulfate [55-48-1] did not influence the toxicity of i.v. administered I. Practolol-HCl [6996-43-6] and metoprolol bitartrate [55250-54-9] antagonized the I-induced tachyarrhythmias. Large doses of the .beta.-blockers enhanced the I-induced bradycardia and increased the incidence of death. .

Stereological quantification of cardiac muscle fiber necroses, a method for pathological physiology and pharmacology

Stereological quantification of cardiac muscle fiber necroses, a method for pathological physiology and pharmacology. Leder, O. (Anat. Inst., Freiburg/Br., Ger.). Prakt. Metallogr., Sonderb., 5(Quant. Anal. Mikrostrukt. Med., Biol. Materialentwickl., Ber. Symp. "Quant. Gefuegeanal."), 129-39 (German) 1975. CODEN: PMSODC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Isoproterenol-HCl-induced myocardial necrosis in rats was inhibited by the Ca2+ antagonists, verapamil-HCl [152-11-4], D-600 [16662-47-8], prenylamine [390-64-7] or calcitonin [9007-12-9] given s.c. or by KCl and(or) MgCl2 given orally. It was enhanced by 9.alpha.-fluorocortisol acetate [514-36-3]. Verapamil and D-600 protected the animals from the potentiating effect of 9.alpha.-fluorocortisol, indicating that Ca2+ are essential for the necrosis-potentiating effect.