Detail of "153832-46-3"

CAS Number:
153832-46-3
Name:
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-,(4R,5S,6S)-
Superlist Name:
Ertapenem
Molecular Structure:
Formula:
C₂₂H₂₅N₃O₇S
Molecular Weight:
475.52
Synonyms:
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-,[4R-[3(3S*,5S*),4a,5b,6b(R*)]]-;UNII-G32F6EID2H;Invanz;
Density:
1.55 g/cm³
Boiling Point:
813.9 °C at 760 mmHg
Flash Point:
446 °C

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Supplier Location
Supplier Location
- China (Mainland)(20)
- India(2)
- United States(1)
- Denmark(1)
Business Type
Business Type
- Lab/Research institutions(2)
- Manufacturers(1)
- Trading Company(19)
Certificates
Certificates
- ISO(1)
- Production License (0)

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis: All Rights Reserved. Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis. Mistry, Goutam C.; Majumdar, Anup K.; Swan, Suzanne; Sica, Domenic; Fisher, Alison; Xu, Yang; Hesney, Michael; Xi, Liwen; Wagner, John A.; Deutsch, Paul J. (Department of Clinical Pharmacology, Rahway, NJ, USA). Journal of Clinical Pharmacology, 46(10), 1128-1138 (English) 2006 Sage Publications. CODEN: JCPCBR. ISSN: 0091-2700. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Ertapenem is a parenteral b-lactam carbapenem antibiotic. This open-label study examd. the pharmacokinetics of single 1-g i.v. doses of ertapenem, administered over 30 min, in patients with mild, moderate, and advanced renal insufficiency (RI) and in patients with end-stage renal disease (ESRD) requiring hemodialysis. Pharmacokinetics were compared with historical controls pooled across healthy young and elderly subjects. Area under the concn.-time curve from time zero to infinity increased 7% in mild, 53% in moderate, 158% in advanced RI, and 192% in ESRD; end of infusion concn. changed minimally; half-life was 4.5 h in the historical control group and 4.4, 6.1, 10.6, and 14. 153832-46-3 which is the cas registry number of one of substances is just one of reagents here.1 h in mild RI, moderate RI, advanced RI, and ESRD, resp. Hemodialysis cleared ~30% of the dose. The recommended dose in mild to moderate RI and after hemodialysis is unchanged at 1 g daily; and in advanced RI and ESRD is reduced to 0.5 g daily. If the daily dose is given 6 h prior to hemodialysis, a supplementary 150-mg dose (30% of the daily dose) is recommended postdialysis. .

Stability of ertapenem in aqueous solutions: All Rights Reserved. Stability of ertapenem in aqueous solutions. Zajac, Marianna; Cielecka-Piontek, Judyta; Jelinska, Anna ( Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan 60-780, Pol.). Journal of Pharmaceutical and Biomedical Analysis, 43(2), 445-449 (English) 2007 Elsevier B.V. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The kinetics of degrdn. of ertapenem was studied in aq. solns. at 303, 313, 323 and 333 K and pH 0.42-12.5. Degrdn. was studied using 2 methods: HPLC (LiChrospher RP-18 column, 5 mm, 250 mm ′ 4 mm; mobile phase: methanol-phosphate buffer 25 mmol l-1, pH 6.5 (, vol./vol.); flow rate-1.2 mL/min; detection UV-298 nm) and UV (294 nm). Specific acid-base catalysis involves: (a) hydrolysis of ertapenem, catalyzed by hydrogen ions; (b) hydrolysis of ertapenem dianions catalyzed by hydroxide ions; (c) spontaneous hydrolysis of zwitter ions and dianions of ertapenem under the influence of water. 153832-46-3 which is the cas registry number of one of substances is just one of reagents here. The thermodn. parameters of these reactions-energy, enthalpy and entropy of activation were calcd. It was obsd. that buffer catalysis occurred in acetate, phosphate and borate buffers. .

Detail of "153832-46-3"

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid,3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-,(4R,5S,6S)-

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

CAS No.153832-46-3 Ertapenem

Reference