Reference

Anticancer activity of isomers of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

Anticancer activity of isomers of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole. Hozumi, Toyoharu; Iwaguchi, Takao; Kitagawa, Hisayo; Ozawa, Hideki (Div. Immunochemother., Tokyo Metrop. Inst. Med. Sci., Tokyo, Japan). Gann, 69(3), 339-43 (English) 1978. CODEN: GANNA2. ISSN: 0016-450X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) When injected i.p. at 5 mg/kg the HCl salts of l- [16595-80-5], d- [16595-76-9], and dl- [5086-74-8] isomers of the title compd. (I) inhibited the relaps of urinary bladder cancer (BC-47 line) in rats treated i.p. with 20 mg BCNU [154-93-8]/kg. I-isomers were injected on day 7 after transplantation of BC-47 tumor line. The l-isomer (levamisole) was most effective. All 3 isomers enhanced the immune response of the host (in plaque forming cell assay) at 5 mg/kg and were equipotent in accelerating blastogenesis in mouse spleen cells. The free base, levamisole [14769-73-4] was not more active than the HCl salt.

Effect of antimicrobial agents on anaerobic digestion

Effect of antimicrobial agents on anaerobic digestion. Van Assche, P.; Poels, J.; Verstraete, W. (Fac. Landbouwwetenschappen, Rijksuniv. Gent, Ghent B-9000, Belg.). Rev. Agric. (Brussels), 37(1), 55-65 (French) 1984. CODEN: RVAGAE. ISSN: 0035-1296. DOCUMENT TYPE: Journal CA Section: 52 (Electrochemical, Radiational, and Thermal Energy Technology) Section cross-reference(s): 16, 18 The antihelminthics Tenac [56645-29-5] and L-Narpenol [16595-80-5], the chemotherapeutics Sulfadiazin [68-35-9] and Furazolidone [67-45-8], and the antibiotic Monesin [1392-52-5] were tested at different concns. At concns. normally used no inhibitory effect on te methanization was obsd. The antihelminthics and chemotherapeutics did not disturb the process even at higher concns. Monensin, however, markedly inhibited the biogas prodn. at 2 mg/L piggery manure. The biogas prodn. from manure of animals fed with Monensin-administered fodder is not advisable unless the residual level of the antibiotic is <0.5 mg/L.