Detail of "171596-29-5"

CAS Number:
171596-29-5
Name:
Cialis
Molecular Structure:
Formula:
C₂₂H₁₉N₃O₄
Molecular Weight:
389.40
Synonyms:
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione,6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R-trans)-;(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;GF 196960;Tadalafil [USAN];Tildenafil;Calais;(6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione;Adcirca;
Density:
1.51 g/cm³
Melting Point:
298-300 °C
Boiling Point:
679.1 °C at 760 mmHg
Flash Point:
364.5 °C
Appearance:
white to off-white cyrstalline solid

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Reference

Electrospray tandem mass spectrometric investigations of tadalafil and its analogue: All Rights Reserved. Electrospray tandem mass spectrometric investigations of tadalafil and its analogue. Zou, Peng; Hou, Peiling; Oh, Sharon Sze-Yin; Low, Min-Yong; Koh, Hwee-Ling (Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543, Singapore). Rapid Communications in Mass Spectrometry, 20(22), 3488-3490 (English) 2006 John Wiley & Sons Ltd. CODEN: RCMSEF.Several reagents with their cas registry numbers 385769-84-6 and 171596-29-5 are used here. ISSN: 0951-4198. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 1, 63 Tadalafil is the active compd. in Cialis, a prescription drug approved by the US FDA in 2003 for penile erectile dysfunction (ED). With the popularity of herbal remedies and dietary supplements, some food and drug manufacturers have added tadalafil or its modified analogs to herbal products for the treatment of ED.'-3 It is potentially dangerous for patients to unknowingly consume dietary supplements adulterated with tadalafil or its analogs. Thus, identification of tadalafil-related compds. in herbal products is important and urgent. In the present study, we have investigated the differences in the mass spectra of tadalafil and its analog. .

A sensitive and simple high performance liquid chromatographic method for quantification of tadalafil in human serum: All Rights Reserved. A sensitive and simple high performance liquid chromatographic method for quantification of tadalafil in human serum. Rabbaa-Khabbaz, Lydia; Daoud, Rita Abi (Bioequivalence and Quality Control Laboratory, Faculty of Pharmacy, Saint-Joseph University, Mathaf, Lebanon). Journal of Applied Research, 6(2), 170-175 (English) 2006 Therapeutic Solutions LLC. CODEN: JAROBP. ISSN: 1537-064X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A simple, rapid, and sensitive high-performance liq. chromatog. method was developed and validated for detn. of tadalafil, a selective and reversible phosphodiesterase inhibitor, in human serum. Methylparaben was used as the internal std. Optimum conditions for tadalafil assay were investigated. The analyte and internal std. were extd. by a single-step liq.-liq. extn. with dichloromethane in alk. serum. The chromatog. sepn. was performed on reverse phase LiChrospher 100, C18 column (Agilent Technologies, Palo Alto, CA) with a mobile phase consisting of 35% acetonitrile-65% water contg. 0.1 mM glacial acetic acid (pH 2.5-2.7). UV detection was performed at 280 nm. Detection limit was 1.5 ng/mL, and limit of quantification was less than 10 ng/mL for tadalafil. The calibration curves were linear over the concn. There are some commonly used reagents like 171596-29-5 in this article. range tested (10-800 ng/mL). Accuracy, precision, and stability studies were satisfactory. This anal. procedure is relatively inexpensive and simple and is particularly suitable when tandem mass spectrometric detection is not available. This method can be used to det. serum tadalafil concns. in drug monitoring or in pharmacokinetic investigations. .

Detail of "171596-29-5"

Cialis

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