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Detail of "18883-66-4"

  • MSDS Download
  • CAS Number:
  • 18883-66-4
  • Name:

  • D-Glucose,2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-

  • Superlist Name:
  • Streptozocin
  • Molecular Structure:
  • Formula:
  • C8H15N3O7
  • Molecular Weight:
  • 265.22 .
  • Synonyms:
  • Glucopyranose,2-deoxy-2-(3-methyl-3-nitrosoureido)-, D- (8CI);Estreptozocin;NSC 37917;NSC85998;STRZ;STZ;Streptozoticin;Streptozotocin;U 9889;Zanosar;
  • EINECS:
  • 242-646-8
  • Density:
  • 1.86 g/cm3
  • Melting Point:
  • 121 °C (dec.)(lit.)
  • Solubility:
  • soluble in water
  • Appearance:
  • off-white to pale yellow crystalline powder
  • Hazard Symbols:
  • HarmfulXn,ToxicT
  • Risk Codes:
  • 40-61-46-45-22-20/21/22
  • Safety:
  • 36/37-53-45-36-22 Details
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CAS No.18883-66-4 Streptozocin

Supplier:Ferro Pfanstiehl Laboratories, Inc. [ United States]

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CAS No.18883-66-4 Streptozocin

  Package:46 kg/vacuum...Storage:store at RT  Transportation:by sea/air  Application:Streptozocin

Supplier:SHAANXI TOP PHARM CHEMICAL CO.LTD [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Category : Intermediates/Pharmaceutical intermediates CAS NO : 18883-66-4 EC NO : 242-646-8 MF : C8H15N3O7 MW : 265.2206 Synonyms : 2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose; 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose;Streptozotocin;2-deoxy-2-{

Supplier:Tianjin Yaoyu Chemicals co.,ltd [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

18883-66-4

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Streptozocin---We supply this product in very competitive price.

Supplier:Hangzhou UNIWISE International Co.,Ltd. [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:LIDE PHARMACEUTICALS LIMITED [ China (Mainland)]

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Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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CAS No.18883-66-4 Streptozocin

Supplier:Hangzhou Imaginechem Co., Ltd [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:Jinan Haohua Industry CO., LTD [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:Afine Chemicals Limited [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Production:

Supplier:GreatAp Chemicals Co.Ltd. [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:Taizhou Chemedir Biopharm-tech Co., Ltd [ China (Mainland)]

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Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China

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CAS No.18883-66-4 Streptozocin

Assay:99%

Supplier:Melone Pharmaceutical Co., ltd [ China (Mainland)]

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Address:No 232, JInma Roda, Development Zone, Dalian, China

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CAS No.18883-66-4 Streptozocin

STREPTOZOTOCIN

Supplier:Waterstone Technology, LLC [ United States]

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Address:12202 Hancock St. Carmel, IN 46032

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CAS No.18883-66-4 Streptozocin

Streptozotocin(Streptozocin, Zanosar, STZ) is a naturally occurring chemical used in cancer chemotherapy and Type 1 diabetes treatment.

Supplier:Selleck Chemicals [ United States]

600Integral
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Address:2626 South Loop West, Suite 225, Houston, TX 77054 USA

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CAS No.18883-66-4 Streptozocin

streptozotocin 1g 600RMB for china mainland

Supplier:shanghai richu bioscience co.,ltd [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

STREPTOZOTOCIN

Supplier:Kainic.com [ United States]

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CAS No.18883-66-4 Streptozocin

more information,pls contact with us!

Supplier:SEQUOIA [ United States]

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Address:10, St James Close,Pangbourne,RG8 7AP,United Kingdom

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CAS No.18883-66-4 Streptozocin

STREPTOZOTOCIN

Supplier:AppliChem GmbH [ Germany]

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Address:Ottoweg 4 DE-64291 Darmstadt Germany

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CAS No.18883-66-4 Streptozocin

more information,pls contact with us!

Supplier:BIOMOL [ United States]

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CAS No.18883-66-4 Streptozocin

Supplier:Seebio Biotech,inc. [ China (Mainland)]

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CAS No.18883-66-4 Streptozocin

Supplier:AXXORA, LLC [ Switzerland]

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CAS No.18883-66-4 Streptozocin

Supplier:Fermentek Ltd [ Israel]

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Tel:972 2 5853953

Address:Yatziv 25, POB 47120, Jerusalem 97800 Israel

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Reference

Effects of streptozotocin on a clonal isolate of rat insulinoma cells
Effects of streptozotocin on a clonal isolate of rat insulinoma cells. Ledoux, Susan P.; Wilson, Glenn L. (Dep. Anat., Univ. South Alabama, Mobile, AL 36688, USA). Biochim. Biophys. Acta, 804(4), 387-92 (English) 1984. CODEN: BBACAQ. ISSN: 0006-3002. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Cytotoxic effects and DNA damage caused by streptozotocin [18883-66-4], a potent b-cell toxin and an important chemotherapeutic agent, in an insulin-secreting clonal isolate of a rat insulinoma cell line were evaluated. Cytotoxicity was monitored by phase-contrast microscopy and measurement of insulin release into the culture medium. DNA damage and repair were assessed by changes in nucleoid sedimentation rates. The insulinoma cells were resistant to streptozotocin toxicity as compared to normal rat b-cells. They were also resistant to stimulatory effects of glucose on insulin release. However, streptozotocin did cause DNA damage that was both dose- and time-dependent. Comparative anal. of streptozotocin-induced DNA damage and that produced by the aglycon N-methyl-N-nitrosourea revealed greater damage with the latter. Thus, streptozotocin, like N-methyl-N-nitrosourea, may enter these cells by passive diffusion rather than selective transport. DNA repair studies indicate that the nicks caused by streptozotocin are sealed and that the DNA is again supercoiled by 14 h. Therefore, overt toxicity may be avoided by a decreased drug uptake compared to normal b-cells and efficient repair mechanisms. Apparently an active glucose-sensing mechanism is necessary to enhance streptozotocin cytotoxicity in both normal and neoplastic b-cells.
Sleep deficits in diabetic rats: restoration following chronic intravenous or intracerebroventricular infusions of insulins
Sleep deficits in diabetic rats: restoration following chronic intravenous or intracerebroventricular infusions of insulins. Danguir, Jaber (Coll. France, CNRS, Paris 75005, Fr.). Brain Res. Bull., 12(6), 641-5 (English) 1984. CODEN: BRBUDU. ISSN: 0361-9230. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The role of insulin in sleep was investigated using streptozotocin [18883-66-4]-induced insulin [9004-10-8] deficiency in rats. The daily duration of both slow wave sleep (SWS) and paradoxical sleep (PS) were decreased on the 3rd day following the injection of streptozotocin. However, only SWS remained lower than the control levels 2 wk after the treatment whereas PS returned to normal values. The continuous i.v. infusion of exogenous insulin (2 IU/24 h) brought about a selective restoration of SWS in insulin-deficient and hyposomniac rats. A dose-dependent restoration of SWS was also obsd. when exogenous insulin was continuously administered intracerebroventricularly in streptozotocin-treated diabetic rats. Although the mechanism of the induction of sleep by insulin remains to be elucidated, these results clearly support its hypnogenic properties. A possible direct action of insulin on brain cells is suggested.
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