Detail of "1944-12-3"

CAS Number:
1944-12-3
Name:
1,3-Benzenediol,5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-, hydrobromide(1:1)
Superlist Name:
Fenoterol hydrobromide
Molecular Structure:
Formula:
C17H21 N O4 . Br H
Molecular Weight:
384.31
Synonyms:
1,3-Benzenediol,5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-, hydrobromide(9CI); Benzyl alcohol, 3,5-dihydroxy-a-[[(p-hydroxy-a-methylphenethyl)amino]methyl]-, hydrobromide (8CI);1-(3,5-Dihydroxyphenyl)-2-[2-(3-p-hydroxyphenyl)propylamino]ethanolhydrobromide; 1-(p-Hydroxyphenyl)-2-(b-3',5'-dihydroxyphenyl-b-hydroxy)ethylaminopropane hydrobromide;3,5-Dihydroxy-a-[(p-hydroxy-a-methylphenethyl)amino]methylbenzylalcohol hydrobromide; 3,5-Dihydroxy-a-[[(p-hydroxy-a-methylphenethyl)amino]methyl]benzyl alc.monohydrobromide; Airum; Berotec; Dosberotec; Fenoterol bromide; Fenoterolhydrobromide; Partusisten; Phenoterol hydrobromide; Th 1165a
Density:
1.289g/cm³
Boiling Point:
566°Cat760mmHg
Flash Point:
203.1°C
Hazard Symbols:
Xn
Risk Codes:
22
Safety:
Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Human reproductive effects by ingestion: changes in the uterus, cervix or vagina. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br⁻ and NO_x. Details

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FENOTEROL HYDROBROMIDE

Supplier:Manus Aktteva, India [ India]

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Supplier:Lusochimica S.P.A. [ Italy]

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Comparative study on the utero-inhibitory effects of some: Comparative study on the utero-inhibitory effects of some .beta.-adrenomimetic drugs. Guevara Rubio, Guillermo; Urzua Leos, Miuel A.; Armas Dominguez, Juan; Karchmer, Samuel (Inst. Mex. Seguro Soc., Hosp. Gineco-Obst., Mexico City, Mex.). Ginecol. Obstet. Mex., 40(5), 363-9 (Spanish) 1976. CODEN: GOMEAY. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Orciprenaline-HCl (I)-HCl) [7104-40-7] (0.28 mg/kg, i.v.) and Th 1165-a [1944-12-3] (0.03 .mu.g/kg/min, i.v.) decreased the tone and intensity, but not the frequency, of uterine contractions of normal term pregnancy patients.

Absorption, distribution and excretion of the tritium-labelled: Absorption, distribution and excretion of the tritium-labelled .beta.2 stimulator fenoterol hydrobromide following aerosol administration and instillation into the bronchial tree. Laros, C. D.; Van Urk, P.; Rominger, K. L. (Dep. Pulm. Dis., St. Antonius Hosp., Utrecht, Neth.). Respiration, 34(3), 131-40 (English) 1977. CODEN: RESPBD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Patients with operable carcinomas of the lung were given tritium-labeled fenoterol hydrobromide (I) [1944-12-3] aerosol immediately before undergoing surgery. In parts of the pulmonary segments the radioactive contents in pulmonary tissue and blood plasma were almost identical. The pharmacokinetic data recorded after aerosol administration, viz. plasma levels and renal excretion, are not different from those recorded after oral administration. The expired air following aerosol administration was examd. in 2 patients, whereby less than 0.1% of the dose administered was recovered. The oropharynx on the other hand, contained 53% of the dose immediately after administration. Absorption via the lungs was examd. in 4 other test persons by instilling an aq. soln. of fenoterol hydrobromide into the right bronchial tree. Comparison of renal excretion levels showed that absorption here was greater than after oral administration; the plasma level curves, however, were very similar.