Reference

N-Acyl nocardicin A derivatives

N-Acyl nocardicin A derivatives. Kamiya, Takashi; Hashimoto, Masashi; Oku, Teruo; Komori, Tadaaki (Fujisawa Pharmaceutical Co., Ltd., Japan). Japan. Kokai JP 52036657 22 Mar 1977 Showa, 7 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D205-08. APPLICATION: JP 75-113381 18 Sep 1975. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) N-acyl derivs. I (R = phthalimido, NHBz, NHCONHPh) were prepd. by acylating I (R = NH2) (II) in a fermn. broth. Thus, 3 L culture filtrate of Nocardia uniformis, contg. 3.5 g II [39391-39-4], was stirred with 15 g N-ethoxycarbonylphthalimide [22509-74-6] in Me2CO at pH 8-8.5 for 3 h and extd. with EtOAc at pH 1.5 to give 3.2 g I (R = phthalimido) [59511-23-8].

Synthesis of (S)-4-amino-2-hydroxy-n-butyric acid and its N-phthaloyl derivative

Horiuchi, Yukio; Akita, Eiichi; Ito, Teiichiro (Cent. Res. Lab., Meiji Seika Kaisha Ltd., Yokohama, Japan). Agric. Biol.In this article, certain chemicals are used. Some of their cas registry numbers are 52429-65-9 and 22509-74-6 Chem., 40(8), 1649-50 (English) 1976. CODEN: ABCHA6. DOCUMENT TYPE: Journal CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 33, 34 H2N(CH2)nCH(OH)CO2H (n = 2-4) were prepd. by converting H2N(CH2)nCH(NH2)CO2H to their Cu complexes, treating these with N-ethoxycarbonylphthalimide, treating I (R = NH2) with NaNO2-aq. HOAc and hydrazinolysis of I (R = OH). .