Reference

The analgesic nefopam (Acupan) lowers body temperature

The analgesic nefopam (Acupan) lowers body temperature. Campos, Victor M. (Hosp. San Juan Dios, San Jose, Costa Rica). Curr. Ther. Res., Clin. Exp., 22(6, Sect. 1), 790-1 (English) 1977. CODEN: CTCEA9. ISSN: 0011-393X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Nefopam-HCl (I) [23327-57-3] lowered body temp. in patients. Of the other drugs tested, only morphine induced a similar hypothermic effect although not of the same duration as I.

Analytical data of nefopam (Ajan), a new analgetic with morphine-like activity

Analytical data of nefopam (Ajan), a new analgetic with morphine-like activity. Ebel, S.; Schutz, H. (Abt. Anal. Chem., Philipps-Univ., Marburg, Ger.). Arch. Toxicol., 38(3), 239-50 (German) 1977. CODEN: ATXKA8. ISSN: 0003-9446. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Results of thin-layer and gas chromatog. anal. of nefopam-HCl (I) [23327-57-3] as well as UV, IR and mass spectra were presented. Nornefopam [46868-19-3] and nefopam-N-oxide [66091-32-5] were the main metabolites. I and nornefopam were extd. from biol. materials following treatment with cyclohexane at pH 11, enzymic hydrolysis of the phenolic component with arylsulfatase/b-glucuronidase and extn. with chloroform/iso-PrOH (4:1) at pH 9.0.