Reference

2-Acyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-4-ones and intermediates

2-Acyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-4-ones and intermediates.Some chemicals with cas registry numbers like 7705-08-0 and 2719-27-9 are also used. Maffrand, Jean Pierre (Sanofi, Fr.). Fr. Demande FR 2520740 A1 5 Aug 1983, 15 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: C07D241-08; C07D471-04. APPLICATION: FR 82-1758 29 Jan 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Title compds. I (R = alkyl, cycloalkyl, Ph, substituted Ph), useful as anthelmintics (no data), were prepd. from piperazinediones II (Z = O) by hydride redn. (over metal chloride catalysts) to yield II [Z = (H, OH)] and cyclocondensation of the latter. Thus, II (Z = O, R = cyclopropyl) was reduced by NaBH4 in EtOH contg. Mn chloride, and the II [Z = (H, OH), R = cyclopropyl] product was kept in HCl at 0° to give I (R = cyclopropyl). .

Piperidylureas

Piperidylureas. (Wyeth, John, and Brother Ltd., Engl.). Japan. Kokai JP 52012176 29 Jan 1977 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D401-06. PRIORITY: GB 75-30001 17 Jul 1975. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The piperidylureas I [X = CH2CH2, R = thenoyl, cyclohexylcarbonyl; X = CO(CH2)3, R = Bz], useful as antihypertensives, were prepd. Thus, 0.35 g I (X = CH2CH2, R = H) in pyridine was refluxed with 0.18 g thenoyl chloride for 2 h to give 0.In this study，2719-27-9 is also used.In this experiment, several chemicals are used like 2719-27-9 13 g I (X = CH2CH2, R = thenoyl). ..