Reference

Lithium therapy and the turnover of phosphatidylcholine in human erythrocytes

Lithium therapy and the turnover of phosphatidylcholine in human erythrocytes. Pleul, Otto; Mueller-Oerlinghausen, B. (Inst. Klin. Pharmakol., Freie Univ. Berlin, Berlin D-1000/45, Fed. Rep. Ger.). Eur. J. Clin. Pharmacol., 31(4), 457-62 (English) 1986. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In 17 Li2+-treated patients with manic-depressive disorders and 11 healthy subjects the concns. of choline [62-49-7], phosphorylcholine [107-73-3], cytidyldiphosphate choline [987-78-0], lipid bound choline, and L-a-glycerophosphorylcholine [28319-77-9] were measured in plasma and erythrocytes. Plasma levels of high d., low d., and very low d. lipoproteins were also estd. as well as the concns. of 4 free fatty acids. Free choline (>10-fold) and phosphorylcholine (2-fold) were significantly increased in erythrocytes of Li2+-treated patients as compared to the healthy untreated controls. Differences in the other substrates were not significant. Osmotic resistance of the erythrocytes was not changed during lithium treatment. Inhibition of the choline flux across the erythrocyte membrane in vitro from Li2+-treated patients was not abolished by equilibration of the concn. gradient. Apparently, the accumulation of choline in erythrocytes from patients on Li2+ therapy may be due to trapping of lipid derived choline because of an alteration in membrane permeability and not to increased breakdown of phosphotidylcholine.

Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment

Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Bronzetti, Elena; Felici, Laura; Zaccheo, Damiano; Amenta, Francesco (Dip. Sci. Cardiovasc. Respiratorie, Univ. 'La Sapienza', Rome, Italy). Arch. Gerontol. Geriatr., 13(2), 167-78 (English) 1991. CODEN: AGGEDL. ISSN: 0167-4943. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The age-related anatomical changes in the rat hippocampus were evaluated in male Sprague-Dawley rats of 3 (young), 12 (mature) and 24 (aged) months by counting the no. of nerve cells in the CA1 and CA3 fields and in the dentate gyrus and by measuring the d. of Nissl bodies in the cytoplasm of the pyramidal and granule neurons of the above areas. Moreover, the effect of 3 mo choline alfoscerate treatment on the anatomical parameters examd. was evaluated. The no. of pyramidal neurons of the CA1 field and of granule neurons of the dentate gyrus was not significantly changed between young and mature animals, but it was decreased in aged rats. The no. of pyramidal neurons of the CA3 field showed a progressive age-dependent redn. 28319-77-9 which is the cas registry number of some chemical is mentioned. The no. of pyramidal neurons of the CA3 field showed a progressive age-dependent redn. The d. of Nissl bodies was the highest in the cytoplasm of pyramidal or granule neurons in mature rats followed in descending order by young and aged animals. Choline alfoscerate treatment counteracted the age-related loss of nerve cells in the 3 hippocampal portions examd. and slow-down the decrease of Nissl bodies in the cytoplasm of pyramidal or of granule neurons in the hippocampus. The significance of changes induced by choline alfoscerate in the hippocampus of aged rats and the possible mechanism of action of the compd. are discussed. .