Reference

External spin-orbit coupling on the 3n,p* state of several cycloalkanones

External spin-orbit coupling on the 3n,p* state of several cycloalkanones. Tro, N. J.; Tro, J. J.; Marten, D. F.; Nishimura, A. M. (Dep. Chem. 107228-43-3 and 29943-42-8 which are cas registry numbers are also used here., Westmont Coll., Santa Barbara, CA 93108, USA). J. Photochem., 36(2), 141-8 (English) 1987. CODEN: JPCMAE. ISSN: 0047-2670. DOCUMENT TYPE: Journal CA Section: 74 (Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes) Section cross-reference(s): 73 The results of a study on the external spin-orbit coupling on the triplet state of several cyclic aliph. ketones by optically detected magnetic resonance are reported. .

Tetrahydro-pyranopyrazole compounds displaying cannabinoid modulating activities and their preparation, pharmaceutical compositions and use in the treatment of CB receptor mediated diseases

All Rights Reserved. Tetrahydro-pyranopyrazole compounds displaying cannabinoid modulating activities and their preparation, pharmaceutical compositions and use in the treatment of CB receptor mediated diseases. Liotta, Fina; Lu, Huajun; Wachter, Michael P. (Janssen Pharmaceutica N.V., Belg.). PCT Int. Appl. WO 2007001939 A1 4 Jan 2007, 77pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization).Several reagents with their cas registry numbers 918546-82-4 and 29943-42-8 are used here. CODEN: PIXXD2. APPLICATION: WO 2006-US23690 16 Jun 2006. PRIORITY: US 2005-694618P 27 Jun 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 This invention is directed to a tetrahydro-pyranopyrazole cannabinoid modulator compd. of formula I: and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease. Compds. of formula I wherein dotted lines in the ring is two double bond, and the remaining bonds are single bonds, and dotted line to X4R4 is an optional double bond; X1, X2 and X4 are independently absent and lower alkylene; X3 is absent, lower alkylene, lower alkylidene, and NH; R1, R2 and R4 are independently H, (un)substituted lower alkylene, lower alkylsulfonyl, (un)substituted aryl, (un)substituted C3-12cycloalkyl, and (un)substituted heterocyclyl; R3 is acyl, sulfonylamino, and carbonylamino; and their pharmaceutically acceptable salts, isomers, prodrugs, metabolites, and polymorphs thereof, are claimed. Example compd. II was prepd. by condensation of tetrahydropyran-4-one with 4-fluorobenzaldehyde; the resulting 3-(4-fluorobenzylidene)tetrahydropyran-4-one underwent acylation with oxalic acid di-Et ester to give 2-[5-(4-benzylidene)-4-oxotetrahydropyran-3-yl]-2-oxoacetic acid Et ester, which underwent cyclization with 2,4-dichlorophenylhydrazine to give the corresponding tetrahydropyranopyrazolecarboxylate, which underwent hydrolysis to give the corresponding tetrahydropyranopyrazole carboxylic acid, which underwent amidation with (R)-1-phenylethanol to give compd. II. All the invention compds. were evaluated for their CB1 receptor binding affinity. From the assay, it was detd. that compd. II exhibited an IC50 valued of 0.013 mM and 87 % binding. .