Reference

Mass fragmentographic analysis of clomipramine and its mono-demethylated metabolite in human plasma

Mass fragmentographic analysis of clomipramine and its mono-demethylated metabolite in human plasma. Alfredsson, Gunnel; Wiesel, Frits Axel; Fyro, Bengt; Sedvall, Goran (Dep. Psychiatry, Karolinska Inst., Stockholm, Swed.). Psychopharmacology (Berlin), 52(1), 25-30 (English) 1977. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A mass fragmentog. method for the quantification of clomipramine (I) [303-49-1] and monodemethylclomipramine (II) [303-48-0] in human plasma was developed. The deuterium labeled analogs of the compds. were used as internal stds. The sensitivity of the method allows the detn. 62724-31-6 and 303-48-0 are cas registry numbers of chemicals which are used as reagents here. of I and II in plasma after oral doses with a std. deviation <7% at concns. of 25 ng/ml. The method was applied to the anal. of drug concns. in plasma of Anafranil (I-HCl) [17321-77-6] treated healthy volunteers and depressed patients. After acute treatment the level of II in plasma was low as compared to chronic treatment. .

Effect of antidepressants on the absorption of serotonin by human thrombocytes

Effect of antidepressants on the absorption of serotonin by human thrombocytes. Oksenkrug, G.In this study， 5118-29-6 and 14368-24-2 are also used. F. (Leningr. Nauchno-Issled. Psikhonevrol. Inst. im. Bekhtereva, Leningrad, USSR). Farmakol. Toksikol. (Moscow), 40(2), 146-8 (Russian) 1977. CODEN: FATOAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) All 15 antidepressants tested decreased the absorption of serotonin [50-67-9] by human thrombocytes in vitro. In decreasing order of effectiveness they were: chlorimipramine [303-49-1], imipramine [50-49-7], prothiaden [113-53-1], quipazine [4774-24-7], amitriptyline [50-48-6], trausabun [5118-29-6], imipramine N-oxide [6829-98-7], nortriptyline [72-69-5], demethylimipramine [50-47-5], trimipramine [739-71-9], noveril [315-80-0], ludiomil [10347-81-6], iprindole [5560-72-5], tacitin [10085-81-1], and origen [14368-24-2]. .