Basic information
- Name:
5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-
- Superlist Name:
- Clomipramine
- CAS No.:
303-49-1
- Molecular Structure:
![Molecular Structure of 303-49-1 (5H-Dibenz[b,f]azepine-5-propanamine,3-chloro-10,11-dihydro-N,N-dimethyl-)](http://www.lookchem.com/300w/2010/0620/303-49-1.jpg)
- Formula:
- C19H23ClN2
- Molecular Weight:
- 314.89
- Deleted CAS:
- 83162-38-3
- Synonyms:
- 5H-Dibenz[b,f]azepine,3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro- (6CI,7CI,8CI);3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine;Chlorimipramine;G 34586;NSC 169865;
- EINECS:
- 206-144-2
- Density:
- 1.119 g/cm3
- Boiling Point:
- 434.2 °C at 760 mmHg
- Flash Point:
- 216.4 °C
- Solubility:
- 25 mg/mL in water
- Hazard Symbols:
Xn- Risk Codes:
- 20/21/22
- Safety Description:
- 36 Details
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
MF: C19H23ClN2
MW: 314.85
MS:
EINECS: 206-144-2
Mol File: 303-49-1.mol
Solubility H2O: 25 mg/mL
Form: powder
color: white to off-white
Surface Tension: 41.7 dyne/cm
Density: 1.119 g/cm3
Flash Point: 216.4 °C
Enthalpy of Vaporization: 69.03 kJ/mol
Boiling Point: 434.2 °C at 760 mmHg
Vapour Pressure: 9.63E-08 mmHg at 25°C
Uses
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine hydrochloride (303-49-1 ) have effects on the performance of a variety of causes and symptoms of depression,Obsessive-compulsive disorder,associated with narcolepsy of cataplexy disorder, panic attacks, phobias, chronic pain state and nocturnal enuresis.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| man | TDLo | oral | 357ug/kg (0.357mg/kg) | gastrointestinal: nausea or vomiting | Journal of Clinical Pyschopharmacology. Vol. 2, Pg. 215, 1982. |
| mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | | Journal of Medicinal Chemistry. Vol. 21, Pg. 448, 1978. |
| mouse | LD50 | intravenous | 27mg/kg (27mg/kg) | | Acta Pharmaceutica Suecica. Vol. 13, Pg. 485, 1976. |
| mouse | LD50 | oral | 380mg/kg (380mg/kg) | behavioral: wakefulness | German Offenlegungsschrift Patent Document. Vol. #2618152, |
| rat | LD50 | intraperitoneal | 149mg/kg (149mg/kg) | | Toxicology. Vol. 24, Pg. 335, 1982. |
| rat | LD50 | oral | 613mg/kg (613mg/kg) | | Toxicology. Vol. 24, Pg. 335, 1982. |
| women | TDLo | intravenous | 3400ug/kg/47M (3.4mg/kg) | behavioral: convulsions or effect on seizure threshold | British Medical Journal. Vol. 3, Pg. 698, 1972. |
| women | TDLo | oral | 10mg/kg/5D-I (10mg/kg) | vascular: bp elevation not characterized in autonomic section | British Medical Journal. Vol. 1, Pg. 406, 1971. |
| women | TDLo | oral | 30mg/kg (30mg/kg) | behavioral: coma | Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 425, 1994 |
Safety Profile
Hazard Codes : Xn .gif){kind=small}
Risk Statements: 20/21/22
20/21/22 : 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine hydrochloride (303-49-1 ) is harmful by inhalation, in contact with skin and if swallowed .
Safety Statements : 36
36: Keep away from sources of ignition - No smoking
WGK Germany: 3
RTECS: HN9055000
Specification
IUPAC Name: 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine hydrochloride (303-49-1 )
CAS: 303-49-1
Synonyms: 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine ; 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine ; 3-Chloroimipramine ; 5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)- ; 5H-Dibenz[b,f]azepine, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro- ; 5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl- ; Anafranil (free base) ; Anafranil base