Detail of "33818-15-4"

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CAS Number:
33818-15-4
Name:
Cytidine5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt,sodium salt (1:1)
Superlist Name:
Citicoline sodium
Molecular Structure:
Formula:
C₁₄H₂₅N₄NaO₁₁P₂
Molecular Weight:
510.31
Synonyms:
Choline,hydroxide, monoester with cytidine 5'-(trihydrogen pyrophosphate), inner salt,monosodium salt (8CI);Cytidine 5'-(trihydrogen diphosphate),P'-[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt;Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester,inner salt, monosodium salt (9CI);Acticolin;Brassel;Cebroton;Cidifos;Flussorex;Gerolin;IP 302 sodium;Logan;Neurotron;Sinkron;
EINECS:
251-689-1
Solubility:
100mg/mL in water
Appearance:
white solid

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CAS No.33818-15-4 Citicoline sodium

Assay:≥99%; Appearance:White powder Package:5kg/barrel,1...Storage:Sealed, in d...

Formula:C14H25N4NaO11P2; Related substances:≤0.5%; Certificate:GMP; File:DMF; Molecular We

Supplier:Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.[ China (Mainland)]

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Reference

Oral pharmaceutical containing cytidine diphosphate choline ester in liposomes: Oral pharmaceutical containing cytidine diphosphate choline ester in liposomes. Moroni, Adolfo (Magis Farmaceutici S.r.l., Italy). Eur. Pat. Appl. EP 114577 A1 1 Aug 1984, 17 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, LI, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K009-50. APPLICATION: EP 83-830007 21 Jan 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) An oral pharmaceutical compn. comprises cytidine diphosphate choline ester (I) [987-78-0] or its salts entrapped in a liposome carrier whose hydrophobic phase is formed by phosphatidylcholine (PC), the ratio of PC to I being 1:1-. A soln. contg. I is added to globules of the hydrophobic phase and lyophilized. The globules are obtained by dissolving the component of the hydrophobic phase in a solvent, pptg. with Me2CO, sepg. the ppt., dispersing it in H2O, evapg. the solvent, and lyophilizing. A tablet formulation contained I Na salt [33818-15-4] 156.76, PC 600, glycine 199.5, levilite 50, Mg stearate 50, talc 50, and Ca phosphate 867 mg. Tests in rats with I carried by a liposome having purified PC from soybean as the hydrophobic phase showed a much higher serum conc. of I at the 6th h than that found after I administration in aq. soln.

Infusion and flushing fluids for the treatment of brain edemas: Infusion and flushing fluids for the treatment of brain edemas. Dittmann, Juergen (Boehringer Mannheim G.m.b.H., Ger.). Ger. Offen. DE 2508474 2 Sep 1976, 31 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-70. APPLICATION: DE 75-2508474 27 Feb 1975. 10043-52-4 and 38099-82-0 which are cas registry numbers are also used here. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacodynamics) Iso- or hypertonic solns. (300-5000 mosmolar) contg. succinate, fructose diphosphate, and 3-phosphoglycerate plus possibly other substances (sugars, inorg. salts, etc.) not only reduce the water content of edematous brain tissue but also stimulate metab. in the tissue. Thus, the swelling of edematous rabbit brain slices was reduced, glucose [50-99-7] consumption by the tissue was enhanced, and lactate [113-21-3] and pyruvate [127-17-3] formation were increased by incubation with a soln. contg. succinic acid [110-15-6] 0.5, Na CDP-choline [33818-15-4] 10, tri-Na fructose, 1,6-diphosphate [38099-82-0] 15, tri-Na 3-phosphoglycerate 15, lactose [63-42-3] 10, and di-Na UDP-glucose [28053-08-9] 5 mM. Similar results were given by infusion of such solns. in vivo. .

Detail of "33818-15-4"

Cytidine5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt,sodium salt (1:1)

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