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| CAS No.: | 372-09-8 |
|---|---|
| Name: | Cyanoacetic acid |
| Article Data: | 78 |
| Molecular Structure: | |
|
|
|
| Formula: | C3H3NO2 |
| Molecular Weight: | 85.0623 |
| Synonyms: | Aceticacid, cyano- (6CI,8CI,9CI);2-Cyanoacetic acid;Malonic mononitrile;Monocyanoacetic acid;NSC 5571; |
| EINECS: | 206-743-9 |
| Density: | 1.287 g/cm3 |
| Melting Point: | 65 °C |
| Boiling Point: | 318.5 °C at 760 mmHg |
| Flash Point: | 107.8 °C |
| Solubility: | 1000 g/L (20 °C) in water |
| Appearance: | yellow-brown liquid with an unpleasant odor |
| Hazard Symbols: |
 C
|
| Risk Codes: | 22-31-34-52/53-20/22 |
| Safety: | 26-36/37/39-45-61-20 |
| Transport Information: | UN 3261 8/PG 2 |
| PSA: | 61.09000 |
| LogP: | -0.01532 |
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Chemistry
Molecular structure of Cyanoacetic acid (CAS NO.372-09-8) is:
Product Name: Cyanoacetic acid
CAS Registry Number: 372-09-8
IUPAC Name: 2-cyanoacetic acid
Molecular Weight: 85.06142 [g/mol]
Molecular Formula: C3H3NO2
XLogP3: -0.8
H-Bond Donor: 1
H-Bond Acceptor: 3
EINECS: 206-743-9
Melting Point: 65 °C
Surface Tension: 57 dyne/cm
Density: 1.287 g/cm3
Flash Point: 107.8 °C
Enthalpy of Vaporization: 61.58 kJ/mol
Boiling Point: 318.5 °C at 760 mmHg
Vapour Pressure: 7.55E-05 mmHg at 25 °C
Storage temp.: Store at 0-5°C
Water Solubility: 1000 g/L (20 °C)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates;C1 to C5;Carbonyl Compounds;Carboxylic Acids
Uses
Cyanoacetic acid (CAS NO.372-09-8) is used for organic synthesis,and also used in the manufacture of Caffeine in medicine
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| frog | LDLo | subcutaneous | 1300mg/kg (1300mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 5, Pg. 161, 1899. |
| mouse | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | National Technical Information Service. Vol. AD691-490, | |
| rabbit | LDLo | subcutaneous | 1900mg/kg (1900mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 5, Pg. 161, 1899. |
| rat | LD50 | oral | 1500mg/kg (1500mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Personal Communication from LONZA Ltd., CH-4002, Basel, SwitzerlandVol. 12JAN1981, |
Safety Profile
Hazard Codes: 
C
Risk Statements: 22-31-34-52/53-20/22
R22:Harmful if swallowed.
R31 :Contact with acids liberates toxic gas.
R34:Causes burns.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R20/22:Harmful by inhalation and if swallowed.
Safety Statements: 26-36/37/39-45-61-20
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S20:When using, do not eat or drink.
RIDADR: UN 3261 8/PG 2
WGK Germany: 2
RTECS: AG3675000
F: 3-10-21
HazardClass: 8
PackingGroup: II
Specification
Cyanoacetic acid , its cas register number is 372-09-8. It also can be called Malonic acid mononitrile ; Malonic mononitrile ; Monocyanoacetic acid ; Acetic acid, 2-cyano- ; Acetic acid, cyano- .It is a yellow-brown liquid with an unpleasant odor and it can sinks and mixes with water.