Reference

Genotoxicity and carcinogenicity of fluorocarbons: assessment by short-term in vitro tests and chronic exposure in rats

Genotoxicity and carcinogenicity of fluorocarbons: assessment by short-term in vitro tests and chronic exposure in rats. Longstaff, E.; Robinson, M.; Bradbrook, C.; Styles, J. A.; Purchase, I. 75-68-3 and 3825-26-1 are also occured in this study. F. H. (Cent. Toxicol. Lab., Imperial Chem. Ind. PLC, Macclesfield/Cheshire SK10 4TJ, UK). Toxicol. Appl. Pharmacol., 72(1), 15-31 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Two short-term in vitro tests for mutagenicity (Salmonella reverse mutation and BHK21 cell transformation) were conducted on a series of fluorocarbons. Some of these materials (FC22 [75-45-6], FC31 [593-70-4], FC142b [75-68-3], FC143 [3825-26-1], and FC143a [420-46-2]) were pos. in 1 or both of the tests and could therefore be considered as being potentially carcinogenic to animals. Rats were dosed for 1 yr by gavage 5 days a week with either FC22, FC31, FC133a, FC134a, or FC143a dissolved in corn oil at a single dosage of 300 mg/kg. The animals were then obsd. until week 125 with detailed necropsy at termination. FC31 was a potent carcinogen (to the rat stomach), a result which reflected the short-term test predictions, but FC133a, which gave a neg. response in both in vitro assays, induced a high incidence of reproductive tract tumors. FC22 and FC143a did not induce tumors, and FC134a was without overt carcinogenic activity. Thus, the short-term tests were only partially successful in identifying potential carcinogens for this series of chems. Fluorocarbon-31 was a potent carcinogen which was 1st identified by bacterial mutation and cell transformation, whereas the equally potent carcinogen FC133a was not so identified. The lack of genotoxic activity with this particular compd. indicates that the carcinogenic activity may be due to mechanisms other than those which involve direct DNA interactions. .

Predicting Gas Transport Coefficients of Alternative Refrigerant Mixtures

All Rights Reserved. Predicting Gas Transport Coefficients of Alternative Refrigerant Mixtures. Moghadasi, J.; Mohammad-Aghaie, D.; Papari, M. M. (Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran). Industrial & Engineering Chemistry Research, 45(26), 9211-9223 (English) 2006 American Chemical Society. CODEN: IECRED. ISSN: 0888-5885. DOCUMENT TYPE: Journal CA Section: 48 (Unit Operations and Processes) Section cross-reference(s): 65 The purpose of this paper is to ext. information about intermol.In this article, certain chemicals are used. Some of their cas registry numbers are 420-46-2 and 431-63-0 pair interaction potential energies of mixts. of ozone-friendly refrigerants by the usage of the inversion method and then to predict the dil. gas transport properties of this class of fluids. The components of studied mixts. are nine environmentally acceptable refrigerants consisting of R125, R134a, R152a, R143a, R32, R236ea, R236fa, R227ea, and RC318. Using the inverted pair potential energies, the Chapman-Enskog scheme is employed to calc. transport properties of the aforementioned systems excluding thermal cond. The calcn. of thermal cond. using inverted pair potential energies through Schreiber's scheme is discussed. In the temp. range 200 K < T < 1000 K, the accuracies of the calcd. viscosities and the thermal conductivities amt. to ±2% and at most ±15%, resp. .