Detail of "4318-56-3"

CAS Number:
4318-56-3
Name:
2,4(1H,3H)-Pyrimidinedione,6-chloro-3-methyl-
Superlist Name:
6-Chloro-3-methyluracil
Molecular Structure:
Formula:
C₅H₅ClN₂O₂
Molecular Weight:
160.55
Synonyms:
Uracil,6-chloro-3-methyl- (7CI,8CI);3-Methyl-6-chlorouracil;6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione;NSC55976;6-Chloro-3-methyl uracil;
Density:
1.51 g/cm³
Melting Point:
278-280°C (dec.)
Boiling Point:
268.7 °C at 760 mmHg
Flash Point:
116.3 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details
Transport Information:
UN 1992

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A new, general synthesis of purines: A new, general synthesis of purines. Yoneda, Fumio; Nagamatsu, Tomohisa (Fac. Pharm. Sci., Kumamoto Univ., Kumamoto, Japan). J. Chem. Soc.Several reagents with their cas registry numbers 4318-56-3 and 61080-30-6 are used here., Perkin Trans. 1, (14), 1547-50 (English) 1976. CODEN: JCPRB4. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 6-Amino-5-nitrosouracil derivs. underwent cyclocondensation reactions with RCH:NNMe2, prepd. in situ by reaction of RCHO with NH2NMe2, to give the corresponding xanthine derivs. Thus, the uracil I with PhCH:NNMe2 in DMF gave 71% II. Alkylation of 9-substituted 1-methylxanthines with excess alkyl halide in DMF in the presence of K2CO3 gave the corresponding 3,7-dialkyl-1-methylxanthine, with elimination of the 9-substituent. Thus, II with EtI and K2CO3 in DMF gave 68% III. Similar treatment of 6-amino-4-hydroxy-5-nitroso-2-phenylpyrimidines with RCH:NNMe2 gave the corresponding purines. Thus, the pyrimidine IV with PhCH:NNMe2 in DMF gave 49% purine V. .

Purines, XII: Purines, XII. Cyclization of 4-alkylamino-5-nitrosouracils and synthesis of 8-substituted xanthines and bis(theophyllin-8-yl)alkane derivatives.In this study，4318-56-3 is also used. Fuchs, Herbert; Gottlieb, Margarete; Pfleiderer, Wolfgang (Fachber. Chem., Univ. Konstanz, Constance, Ger.There are some reagents like 4318-56-3 is used in this study.). Chem. Ber., 111(3), 982-95 (German) 1978. CODEN: CHBEAM. ISSN: 0009-2940. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Uracils I (R = Me, CHMe2, cyclohexyl, Ph; R1 = Et, Pr, Bu, CH2Ph, allyl, CHMe2, cyclohexyl, Ph; R2 = Me, CHMe2, CH2Ph, CH2CH2Ph, cyclohexyl, tetrahydrofurfuryl, R3 = H) were prepd. by chlorinating pyrimidinetriones followed by amination. I (R3 = NO) were obtained by nitrosating I (R3 = H) and in some cases were cyclized to xanthines II (R = R1 = Ph, R4 = H, Ph, CH2Ph, 2-tetrahydrofuryl; R = R1 = Me, R4 = 2-tetrahydrofuryl). Bis(uracilylamino)alkanes III (R3 = H, n = 0-8) werre prepd. by treating 4-chloro-1,3-dimethyluracil with H2NCH2(CH2)nCH2NH2 and were nitrosated to give III (R3 = NO), which cyclized to IV. ..