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Detail of "446-86-6"

  • MSDS Download
  • CAS Number:
  • 446-86-6
  • Name:

  • Azathioprine

  • Molecular Structure:
  • Formula:
  • C9H7N7O2S
  • Molecular Weight:
  • 277.29
  • Synonyms:
  • 1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]- (6CI,8CI);6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Azamune;Azanin;Azathioprin;Azoran;BW 57-322;Imuran;Imurek;Imurel;Muran;NSC 39084;
  • EINECS:
  • 207-175-4
  • Density:
  • 1.9 g/cm3
  • Melting Point:
  • 243-244 °C
  • Boiling Point:
  • 685.7 °C at 760 mmHg
  • Flash Point:
  • 368.5 °C
  • Solubility:
  • <0.1 g/100 mL at 23 °C in water
  • Appearance:
  • Yellow solid
  • Hazard Symbols:
  • HarmfulXn, ToxicT, IrritantXi
  • Risk Codes:
  • 45-22-36/37/38-20/21/22
  • Safety:
  • 53-22-26-36/37-45-36 Details
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CAS No.446-86-6 AzathioprineCompetitive Product

Storage:Store at RT  Transportation:by air/sea

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Assay:98.0-101.5%  Appearance:light yellow...  Package:25 kgs/ fibe...Storage:Store at roo...  Transportation:deliver with...  Application:Health and m...

Molecular Formula: C9H7N7O2S Molecular Weight: 277.26 standard: USP32 Function: The product is widely used for rheumatoid arthritis, systemic lupus erythematosus, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, active chronic hepatitis, ulcerative coliti

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Gladys In vitro and in vivo experiments on the immunosuppressive effects of cytostatic substances In vitro and in vivo experiments on the immunosuppressive effects of cytostatic substances. Schuppli, R. (Dermatol. Universitaetsklin., Kantonssp. 7440-38-2 and 51-21-8 are cas reg

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CAS No.446-86-6 Azathioprine

Molecular Formula:C9H7N7O2S Molecular Weight:277.29 Density:1.9 g/cm3 Melting Point:243-244 oC Boiling Point:685.7 °C at 760 mmHg Flash Point:368.5 °C Solubility:<0.1 g/100 mL at 23 oC in water Appearance:Light-yellow crystalline powder Standard: USP28

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Product Name: Azathioprine Synonyms: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine; 6-(Methyl-p-nitro-5-imidazolyl)-thiopurine Molecular Formula: C9H7N7O2S Molecular Weight: 277.26 Specification: USP Usage

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Azathioprine(Azasan, Imuran) is a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease.

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Formula : C9H7N702S Cas No.: 446-86-6

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Reference

In vitro and in vivo experiments on the immunosuppressive effects of cytostatic substances
In vitro and in vivo experiments on the immunosuppressive effects of cytostatic substances. Schuppli, R. (Dermatol. Universitaetsklin., Kantonssp. 7440-38-2 and 51-21-8 are cas registry numbers. These chemicals are also mentioned in this article. Basel, Basel, Switz.). Dermatologica, 152(5), 289-94 (German) 1976. CODEN: DERAAC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In equimolar concns., 5-fluorouracil (I) [51-21-8], As, Imurel [446-86-6], Oncovin [2068-78-2], methotrexate (II) [59-05-2], and Endoxan [50-18-0] had different abilities to inhibit the phytohemagglutinin-stimulated transformation of human lymphocyte in vitro. The 1st 3 substances were completely inhibitory at 10-1-10-2 mM, whereas II was less active and Endoxan inactive. Only II, given i.p. at 0.1 mg/kg, was able to inhibit dinitrochlorobenzene-induced contact eczema in guinea pigs in vivo. Thus, in vitro cytostatic results with immunosuppressants cannot be simply extrapolated to the living animal. Because of the relative simplicity, the guinea pig eczema test is suitable for studying the immunosuppressant action of various substances. .
Differences in the effects of antiblastic drugs on hemopoietic stem cells after erythropoietic activation
Differences in the effects of antiblastic drugs on hemopoietic stem cells after erythropoietic activation. Bogliolo, Giuseppe; Saviane, Alberto; Massa, Giulio; Ghio, Riccardo; Bianchi, Giovanna; Pannacciulli, Ivo (Ist. Sci. 865-21-4 and 50-18-0 are also occured in this study. Med. Interna, Genoa, Italy). Tumori, 62(4), 445-54 (Italian) 1976. CODEN: TUMOAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effects of cyclophosphamide (I) [50-18-0] (200 mg/kg), vinblastine (II) [865-21-4] (4 mg/kg), and azathioprine (III) [446-86-6](300 mg/kg), injected i.p. into mice 2 days after erythropoietic stimulation by bleeding, were detd. on pluripotent stem cells (those able to form bone marrow and spleen colonies in vivo) and on monopotent stem cells (those able to form colonies in vitro in response to colony-stimulating factor or erythropoietin). There were differences in the behavior of the 2 groups of stem cells, both with respect to each other and with respect to the results in nonbled mice. The behavior of the different types of stem cells seemed to be due mainly to the different nos. present at the time of drug administration. The difficulty is stressed of being able to predict changes in sensitivity of marrow precursor cells to antiblastic drugs according to the extent of marrow activation or homeostasis. .
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