Reference

In vitro adsorption of bile salts and aspirin to sucralfate

In vitro adsorption of bile salts and aspirin to sucralfate. Graham, David Y.; Sackman, Jeffrey W.; Giesing, Dennis H.; Runser, Dennis, J. (Houston Veterans Adm. Med. Cent., Baylor Coll. Med., Houston, TX, USA). Dig. Dis. Sci., 29(5), 402-6 (English) 1984. CODEN: DDSCDJ. ISSN: 0163-2116. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The in vitro adsorption of bile salts or aspirin [50-78-2] to sucralfate (I) [54182-58-0] in environments simulating the stomach (pH 1.5), small intestine (pH 7), and colon (pH 7.8) was detd. Bile salts were incubated with sucralfate,and the quantity of bile salt adsorbed was calcd. by subtraction from the amt. remaining in soln. after centrifugation at 12,500g for 30 min. Adsorption expts. were performed in bile salt solns. at pH 1.5 and 7.0 with 0-10 g/dL sucralfate using glycocholate [475-31-0], glycochenodeoxycholate [640-79-9], taurocholate [81-24-3], taurodeoxycholate [516-50-7], or taurochenodeoxycholate [516-35-8]. The dihydroxy-unconjugated bile salts, deoxycholate [83-44-3], and chenodeoxycholate [474-25-9] were tested at pH 7.8. Binding capacity (mmoles/g sucralfate) was calcd. from the linear regression of mmoles bound vs g sucralfate incubated. Sucralfate adsorbed all bile salts tested (except taurocholate at pH 1.5) but was less effective than cholestyramine. Sucralfate does not adsorb sufficient bile salts at neutral pH to cause bile salt depletion. Aspirin was minimally adsorbed by sucralfate [7.5 mmol (1.4 mg)/g sucralfate, pH 1.5], and thus adsorption of aspirin does not explain the protective effect of sucralfate against aspirin injury.

Lipid transport in hypokinesia and protein deficiency

Lipid transport in hypokinesia and protein deficiency. Sharmanov, T. Sh. (Inst. Nutr., Alma-Ata, USSR). Ukr. Biokhim. Zh., 56(3), 293-301 (Russian) 1984. CODEN: UBZHD4. ISSN: 0201-8470. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Section cross-reference(s): 13 In expts. with humans and lab. animals (rats), correlations between various lipids and bile acids in bile and between bile cholesterol [57-88-5] and bile acids and serum lipoproteins were noted, and a model describing lipid transport in liver, bile, and serum was drawn. Protein deficiency tended to decrease liver very-low-d. lipoproteins and their triglyceride content, liver microsomal phospholipids, and bile taurocholic acid [81-24-3] and primary cholates, and increased liver microsomal triglycerides and free and esterified cholesterol, and bile glycocholic acid [475-31-0]. Hypokinesia made liver microsomal mixed function oxidase [9040-60-2] more receptive to cytochrome P 450 and vitamin B5 and less activated by glycocholic acid. Other effects of protein deficiency and hypokinesia are discussed.