Reference

Hymenolepis nana: maturation in an immunosuppressed unnatural rat host

Hymenolepis nana: maturation in an immunosuppressed unnatural rat host. Ito, Akira (Sch. Med., Gifu Univ., Gifu 500, Japan). Exp. Parasitol., 56(3), 318-26 (English) 1983. CODEN: EXPAAA. ISSN: 0014-4894. DOCUMENT TYPE: Journal CA Section: 15 (Immunochemistry) When eggs of the dwarf tapeworm, H. nana, cycled exclusively and directly through mice for >10 yr, were inoculated into previously uninfected inbred Fischer (F344) rats, they failed to mature in the rat intestinal lumen. Eggs of H. nana inoculated into the rat developed normally into cysticercoids (cysts) in the intestinal tissue, but thereafter failed to mature in the lumen except when the host was treated with cortisone acetate from the day of cyst maturation. 53-06-5 and 50-18-0 which are cas registry numbers are also used here. The Fischer rat initially given eggs of H. nana became completely immune to egg challenge within 2 days of egg inoculation: no cysts derived from challenge eggs were found in the immunized rat. Immunosuppression, assessed by the success of cyst recovery in the tissue 4 days after egg challenge, had no promotive effect on the recovery of adult worms derived from eggs initially inoculated. Rats initially given eggs and immunosuppressed by cyclophosphamide or antithymocyte serum did not harbor any adult worms. Cortisone acetate treatment which was sufficient for inoculated eggs to mature (a total of 75 or even 200 mg, from day 5 of egg inoculation) had no immunosuppressive effects, whereas cortisone acetate treatment which was sufficient for immunosuppression (a total of 150 mg from day 2, 2 days prior to the initial egg inoculation) induced some adult formation as well. In addn., when mouse-derived cysts were inoculated into the rat instead of eggs, they also failed completely to mature, even when the rat was treated with cyclophosphamide or antithymocyte serum. However, when the rat was treated with cortisone acetate from the day of cyst inoculation, the cysts developed into adult worms. Thus, the Fischer rat clearly differs in its susceptibility to the tissue phase of egg inoculation and to the lumen phase of cyst inoculation of H. nana; the failure of maturation of H. nana in the unnatural host, Fischer rats, may not be attributable to innate and(or) acquired immunity of the rat but to other nonimmunol. mechanisms. .

Antiviral activity of interferon in rats and the effect of immune suppression

Antiviral activity of interferon in rats and the effect of immune suppression. Schellekens, H.; Smiers-de Vreede, E.; De Reus, A.; Dijkema, R. (Primate Cent., TNO, Rijswijk 2280 HV, Neth.).There are some reagents like 50-18-0 is used in this study. J. Gen. Virol., 65(2), 391-6 (English) 1984. CODEN: JGVIAY. ISSN: 0022-1317. DOCUMENT TYPE: Journal CA Section: 15 (Immunochemistry) The antiviral effect of interferon was studied in a no. of exptl. virus infections in the rat. Interferon protects rats infected with pseudorabies virus, herpes simplex virus, or vesicular stomatitis virus. The antiviral activity was not inhibited by immune suppression induced by azothioprine, prednisolone, or cyclosporin A treatment. Cyclophosphamide completely blocked the in vivo activity of interferon in rats. .