Reference

Prostaglandins and human gastric mucosa: molecular aspects and protective properties

Prostaglandins and human gastric mucosa: molecular aspects and protective properties. Mueller, P.; Dammann, H.Several substances are used for example 4510-16-1 and 78413-44-2 which are their cas registry numbers. G.; Simon, B.; Kommerell, B. (Med. Univ. Clin. Heidelberg, Heidelberg 6900, Fed. Rep. Ger.). Mech. Mucosal Prot. Upper Gastrointest. Tract, 311-16. Edited by: Allen, Adrian. Raven: New York, N. Y. (English) 1984. CODEN: 50WXA8. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) Of the prostaglandins showing cytoprotective effects to ulcerogenic stimuli in human gastric mucosa, PGE2 [363-24-6], PGI2 [35121-78-9], 15(S)methyl-PGF2b [35700-24-4], and PGF2b [4510-16-1] stimulated adenylate cyclase [9012-42-4] activity in samples of human gastric mucosa, whereas SC-29333 [59122-46-2] and C 83 [78413-44-2] inhibited the activity. In contrast, PGD2 [41598-07-6] showed an antiulcer effect on the gastric mucosa but had no no effect on the adenylate cyclase system. In addn., prostaglandins prevent the decrease in transmucosal p.d. induced by aspirin [50-78-2] and taurocholate [81-24-3] in doses which are smaller than the antisecretory doses, indicating that these 2 properties are independent of one another. .

Effect of chronic ingestion of a prostaglandin E analog on immunologic function in healthy elderly subjects

Effect of chronic ingestion of a prostaglandin E analog on immunologic function in healthy elderly subjects. Goodwin, James S.; Clay, George A. (Dep. Med., Med. Coll. Wisconsin, Milwaukee, WI 53226, USA). Int. J. Immunopharmacol., 8(8), 867-73 (English) 1986. CODEN: IJIMDS. ISSN: 0192-0561. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The immunol. effects of an oral PGE analog (misoprostol (I) [59122-46-2]) were tested in individuals over age 65, as compared with individuals given placebo. After 2 wk of ingestion of I or placebo, there was a small but statistically significant decrease in IgM-rheumatoid factor in the I-treated group compared with control and a significant decrease in the in vitro sensitivity of lymphocytes from the I-treated group to inhibition by prostaglandin E. There were no differences in total lymphocyte count, T cell or T cell subset count, delayed hypersensitivity skin test reactivity, serum Igs, or response to mitogens between the 2 groups. Administration of I to normal elderly individuals is not assocd. with any detrimental effects on immunol. function after 2 wk.