Detail of "59649-56-8"

Reference

Preparation of quinoxaline and pyrido[2,3-b]pyrazine derivatives as PKB inhibitors for treatment of cancers

Preparation of quinoxaline and pyrido[2,3-b]pyrazine derivatives as PKB inhibitors for treatment of cancers. Kawakami, Joel; Duncton, Matthew; Sherman, Dan; He, Hai-Ying; Kiselyov, Alexander; Pytowski, Bronek (Imclone Systems Incorporated, USA). PCT Int. Appl. WO 2005007099 A2 27 Jan 2005, 126 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2004-US21834 9 Jul 2004. PRIORITY: US 2003-PV486339 10 Jul 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. represented by the formula I [wherein X = N or C; R1, R2 = independently H, (cyclo)alkyl, alkoxy, heterocyclyl(alkyl), (hetero)aryl, (hetero)aralkyl, (un)substituted amino; R3-R6 = independently H, cyano, (hetero)aryl, (cyclo)alkyl, etc.; with a proviso] were prepd. as PKB inhibitors. For example, reaction of 4,5-diaminopyrimidine with 2,2'-thenyl gave II in 19% yield. I were tested for inhibition of PKB in PKBa, PKBb and PKBg in vitro kinase assay. Thus, I and their pharmaceutical compns. 59649-56-8 and 103-71-9 are just another two chemicals used in this study. are useful as PKB inhibitors for the treatment of cancers, or the inhibition of tumor growth. .

a-(2-Furyl)quinoxalines and -2-quinoxalones with a substituent in the benzene ring

a-(2-Furyl)quinoxalines and -2-quinoxalones with a substituent in the benzene ring. Saldabols, N.; Cimanis, A.; Liepins, E.; Yankovskaya, I. S. (Inst. Org. Sint., Riga, USSR). Khim. Geterotsikl. Soedin., (10), 1311-14 (Russian) 1977. CODEN: KGSSAQ. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Furylquinoxalines I (R = 6-, 7-NO2) were obtained as a mixt. by cyclocondensation of 2-furanglyoxal or its oxime with 3,4-(H2N)2C6H3NO2 in dioxane or 3N HCl.Several substances like 59649-56-8 may be metioned in this study. Condensation of 2-furanglyoxalic acid with 2,3-(H2N)2C6H3OH gave a mixt. of quinaxalones II (R = 5-OH and 8-OH), and condensation of 2-furanglyoxalic acid with 3,4-(H2N)2C6H3NO2 gave gave a mixt. of II (R = 6-NO2 and 7-NO2). Nitration of II (R = 6-NO2) gave the corresponding 5-nitrofuryl deriv., which was also obtained by cyclocondensation of Et 5-nitrofuranglyoxalate with 3,4-(H2N)2C6H3NO2. 59649-56-8 is just another one chemical used in this study. ..