CAS No.612-12-4,1,2-Bis(chloromethyl)benzene Suppliers

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Basic Information

Molecular Structure:
CAS No.:	612-12-4
Name:	1,2-Bis(chloromethyl)benzene
Article Data:	23

Formula:	C₈H₈Cl₂
Molecular Weight:	175.058
Synonyms:	o-Xylene, a,a'-dichloro- (7CI,8CI);NSC 71934;o-Bis(chloromethyl)benzene;o-Xylene-a,a'-dichloride;o-Xylylene dichloride;a,a'-Dichloro-o-xylene;
EINECS:	210-291-8
Density:	1.208 g/cm³
Melting Point:	51-55 °C(lit.)
Boiling Point:	239.5 °C at 760 mmHg
Flash Point:	114.1 °C
Solubility:	hydrolysis with water
Appearance:	white to light yellow crystal powder
Hazard Symbols:	C, Xi
Risk Codes:	34-36/37-36/37/38-50/53-26-22-36
Safety:	26-27-28-36/37/39-45-24/25-61-29-28A
Transport Information:	UN 3261 8/PG 2
PSA:	0.00000
LogP:	3.16420

Synthetic route

: 612-14-6
phthalyl alcohol

A: 496-14-0
1,3-dihydroisobenzofuran

B: 612-12-4
o-Xylylene dichloride

C: 142066-41-9
2-(chloromethyl)-phenyl methanol

Conditions

Conditions	Yield
With hydrogenchloride In water at 70℃; for 1h;	A n/a B n/a C 91%

...Expand

: 98-07-7
Benzotrichlorid

: 612-14-6
phthalyl alcohol

A: 98-87-3
benzylidene dichloride

B: 612-12-4
o-Xylylene dichloride

Conditions

Conditions	Yield
With TOP; phenylsilane In neat (no solvent) at 100℃; for 24h; Appel Halogenation; Inert atmosphere;	A n/a B 65%

...Expand

: 95-47-6
o-xylene

A: 612-12-4
o-Xylylene dichloride

B: 30293-58-4
α,α,α'-trichloro-o-xylene

C: 60973-59-3
α,α-dichloro-o-xylene

D: 552-45-4
1-chloromethyl-2-methylbenzene

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); chlorine at 90℃; for 4h;	A 50.5% B n/a C n/a D n/a

...Expand

: 128-09-6
N-chloro-succinimide

: 95-47-6
o-xylene

: 612-12-4
o-Xylylene dichloride

Conditions

Conditions	Yield
Irradiation.UV-Licht;

: 128-09-6
N-chloro-succinimide

: 95-47-6
o-xylene

A: 612-12-4
o-Xylylene dichloride

B: 552-45-4
1-chloromethyl-2-methylbenzene

Conditions

Conditions	Yield
UV-Licht.Irradiation;

...Expand

: 95-47-6
o-xylene

: 612-12-4
o-Xylylene dichloride

Conditions

Conditions	Yield
With phosphorus pentachloride at 190℃;
durch Chlorierung im Sonnenlicht;
With chlorine Irradiation;

: 131-11-3
phthalic acid dimethyl ester

: 612-12-4
o-Xylylene dichloride

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether Erhitzen des Reaktionsgemisches mit konz. wss. Salzsaeure;

: 861338-62-7
bis-(2-ethoxymethyl-benzyl)-amine

A: 612-12-4
o-Xylylene dichloride

B: 38379-25-8
o-chloromethylbenzylamine

Conditions

Conditions	Yield
With hydrogenchloride; ethanol

: 50-00-0
formaldehyd

: 100-44-7
benzyl chloride

A: 612-12-4
o-Xylylene dichloride

B: 623-25-6
p-Xylylene dichloride

Conditions

Conditions	Yield
With zinc(II) chloride at 80℃; Einleiten von HCl;
With aluminium trichloride; 1,2-dichloro-ethane; zinc(II) chloride at 50℃; Einleiten von HCl;

...Expand

: 612-14-6
phthalyl alcohol

: 612-12-4
o-Xylylene dichloride

Conditions

Conditions	Yield
With hydrogenchloride
With acetyl chloride; zinc(II) chloride
With tetrachloromethane; triphenylphosphine

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Chemistry

The molecular structure of α,α'-Dichloro-o-xylene (612-12-4) as follow:
EINECS: 210-291-8
Molecular formula: C₈H₈Cl₂
Formula weight: 175.06
Synonyms: 1,2-Bis(chloromethyl)benzene ; o-Xylylene dichloride ; o-Bis(chloromethyl)benzene ; Benzene,1,2-bis(chloromethyl)-
Density: 1.208 g/cm³
Melting point: 51-55 ℃(lit.)
Boiling point: 239-241 ℃(lit.)
Flash point: 107 ℃
Index of refraction: 1.544
Vapour pressure: 0.0618 mmHg at 25 ℃
Appearance: white to light yellow crystal powder
α,α'-Dichloro-o-xylene (612-12-4) can hydrolysis in water. The product categories about it belong to pharmaceutical intermediates.

Uses

α,α'-Dichloro-o-xylene(612-12-4) is used as pharmaceutical, chemical and pesticide intermediates.

Toxicity Data With Reference

mouse	LD₅₀	intravenous	320mg/kg (320mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03225,
mouse	LD₅₀	oral	1131mg/kg (1131mg/kg)	BEHAVIORAL:SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	National Technical Information Service. Vol. OTS0555290,
rat	LD₅₀	oral	2263mg/kg (2263mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	National Technical Information Service. Vol. OTS0555290,

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Poison by intravenous route. Mutation data reported. See also CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic Cl⁻.

Hazard codes: C Corrosive Xi Irriitant
Risk statements: 22 Harmful if swallowed.
                       26 Very toxic by inhalation.
                       34 Causes burns.
                       36 Irritating to the eyes.
                       36/37 Irritating to eyes and respiratory system.
                       36/37/38 Irritating to eyes, respiratory system and skin.
                       50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety statements: 24/25 Avoid contact with skin and eyes.
                           26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                           27 Take off immediately all contaminated clothing.
                           28A After contact with skin, wash immediately with plenty of water.
                           29 Do not empty into drains.
                           36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
                           45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                           61 Avoid release to the environment. Refer to special instructions/safety data sheets.

Specification

α,α'-Dichloro-o-xylene (612-12-4) is stable at room temperature in closed containers under normal storage and handling conditions. It must be away from incompatible substances such as strong oxidizing agents, bases, alcohols, aluminum and amines. Its hazardous decomposition products are hydrogen chloride, phosgene, carbon monoxide and carbon dioxide. The hazardous polymerization of α,α'-Dichloro-o-xylene (612-12-4) has not been reported.