Reference

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

Synthesis and identification of the major metabolites of prazosin formed in dog and rat. Althuis, T. H.; Hess, H. J. (Med. Res. 60547-93-5 and 6346-05-0 are cas registry numbers. These chemicals are also mentioned in this article. Lab., Pfizer, Inc., Groton, Conn., USA). J. Med. Chem., 20(1), 146-9 (English) 1976. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 The 6-O-demethyl (I-H2SO4) [60548-10-9] and 7-O-demethyl (II-H2SO4) [60548-11-0] analogs of prazosin-HCl (III-HCl) [19237-84-4] were prepd. and I and II were found to be identical with major and significant metabolites of III in dogs and rats, but had less potent blood pressure lowering activity than III in dogs. I and II were prepd. from isovanillin [621-59-0] and vanillin [121-33-5], resp., in 10-step reaction sequences. Two minor metabolites of III, 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline-2HCl [60548-08-5] and 2,4-diamino-6,7-dimethoxyquinazoline [60547-96-8] were prepd. and detd. to have low hypotensive activity. .

Adsorption of vanillin and isovanillin on a bismuth electrode

Adsorption of vanillin and isovanillin on a bismuth electrode. Chaika, L. V.; Nesterenko, A. F.; Kudina, I. P.; Loshkarev, M. A. (USSR). Vopr. Khim. Khim. Tekhnol., 46, 56-9 (Russian) 1977. CODEN: VKKCAJ. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 66 The adsorption was studied of vanillin (I) [121-33-5] and isovanillin (II) [621-59-0] by Bi. Capacitance vs. potential curves of Bi electrodes in 1N Na2SO4 in the presence of I and II at pH 3 and 6 were studied. The amt. of additive was 5 ′ 10-3 mol/L.