Reference

Rapid one-pot method for deprotection of ribonucleotide-containing oligonucleotides using aqueous methylamine and followed by triethylammonium trihydrofluoride

Rapid one-pot method for deprotection of ribonucleotide-containing oligonucleotides using aqueous methylamine and followed by triethylammonium trihydrofluoride. Vargeese, Chandra; Shaffer, Christopher; Bowman, Keith (Sirna Therapeutics, Inc.Several substances are used for example 648411-05-6 and 73602-61-6 which are their cas registry numbers., USA). PCT Int. Appl. WO 2004007748 A2 22 Jan 2004, 74 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C12Q. APPLICATION: WO 2003-US21775 14 Jul 2003. PRIORITY: US 2002-194875 12 Jul 2002. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) A rapid, one-pot method for deprotection of nucleic acid mols. or oligonucleotides comprising one or more ribonucleotides is disclosed. Such nucleic acid mols. include siRNA, dsRNA, ribozymes, antisense, and aptamers. The method comprises use of aq. MeNH2 to partially deprotect the oligonucleotides followed by treatment with TEA.3HF to complete the deprotection. Oligonucleotides contg. ribonucleotides protected with t-butyldimethylsilyl groups and those contg. 2'-deoxy-2'-aminoribonucleotides with N-phthaloyl protecting groups can be rapidly deprotected. .

Selective electrochemical synthesis of 4-fluoropyridine using Et3N×3HF

Selective electrochemical synthesis of 4-fluoropyridine using Et3N×3HF. Fang, Bin; Tao, Haisheng; Kan, Xianwen; Shang, Yongjia (College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, Peop. 73602-61-6 and 694-52-0 are also occured in this study. Rep. China). Heterocyclic Communications, 10(4-5), 305-306 (English) 2004 Freund Publishing House Ltd. CODEN: HCOMEX. ISSN: 0793-0283. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 27 Pyridine was electrochem. fluorinated at platinum anode at const. voltage in acetonitrile solns. contg. Et3N×3HF, as supporting electrolytes and fluorine sources. The present electrolyte soln. system was mild and suitable for the fluorination of pyridine. Thus, 4-fluoropyridine has been synthesized. .