Reference

Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon

Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat jejunum, ileum and colon. Autore, G.; Capasso, F.; Mascolo, N. (Sch. Pharm., Univ. Naples, Naples 80138, Italy). Br. J. Pharmacol., 81(2), 347-9 (English) 1984. CODEN: BJPCBM. ISSN: 0007-1188. 77-09-8 and 51-45-6 which are cas registry numbers of chemicals are mentioned. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The effects of phenolphthalein [77-09-8] on the formation of histamine [51-45-6], 5-HT [50-67-9], and prostaglandin-like material by the rat jejunum, ileum, and colon were examd. in vivo. Phenolphthalein, in a dose that causes laxation increased the formation of histamine, 5-HT, and prostaglandin-like material, and indomethacin reduced these increases. The laxative effect of phenolphthalein may be due to increased intestinal prodn. of prostaglandin, histamine, and 5-HT. .

Suppression of laxative action of phenolphthalein by orally administered indomethacin or aspirin

Suppression of laxative action of phenolphthalein by orally administered indomethacin or aspirin. Capasso, F.; Mascolo, N.; Autore, G.; Duraccio, M. R. (Sch. Pharm., Univ. Naples, Naples 80138, Italy). J. Pharm. Pharmacol., 36(2), 132-3 (English) 1984. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oral administration of phenolphthalein (I) [77-09-8] produced a dose-dependent increase of wet feces excreted by mice.In this experiment, several chemicals are used like 53-86-1 and 77-09-8 The response to phenolphthalein was reduced by pretreatment with indomethacin [53-86-1], aspirin [50-78-2], or polyphloretin phosphate (PPP) [9014-72-6], but not with benoxaprofen [51234-28-7]. These findings support the view that the effect of phenolphthalein may be suppressed by prostaglandin synthetase inhibitors. .