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78137-76-5

Basic Information
CAS No.: 78137-76-5
Name: 4-Bromo-3-nitrophenol
Article Data: 15
Molecular Structure:
Molecular Structure of 78137-76-5 (4-Bromo-3-nitrophenol)
Formula: C6H4BrNO3
Molecular Weight: 218.007
Synonyms: 2-Bromo-5-hydroxynitrobenzene;4-Bromo-3-nitrophenol;
Density: 1.881 g/cm3
Melting Point: 144-145 ºC
Boiling Point: 281 ºC at 760 mmHg
Flash Point: 124 ºC
PSA: 66.05000
LogP: 2.58610
Synthetic route
554-84-7

meta-nitrophenol

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
With 1-butyl-3-methylpyridinium tribromide at 20℃;98%
With 1,3-di-n-butyl-1H-imidazol-3-ium tribromide at 20℃; for 0.133333h; Neat (no solvent); regioselective reaction;95%
With 1,2-ethanediylbis(triphenylphosphonium) ditribromide In methanol; dichloromethane at 20℃; for 0.0833333h; Solvent; regioselective reaction;85%
at 120 - 140℃; Einleiten von mit CO2 verduenntem Brom-Dampf;
With hydrogenchloride; carbon dioxide; bromine
5344-78-5

4-bromo-3-nitroanizole

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
Stage #1: 4-bromo-3-nitroanizole With boron tribromide In dichloromethane at -78 - 20℃; for 31h;
Stage #2: With water In dichloromethane at 0℃;
87%
Stage #1: 4-bromo-3-nitroanizole With boron tribromide In dichloromethane at -78 - 20℃; for 31h;
Stage #2: With water In dichloromethane at 0℃;
87%
With boron tribromide In dichloromethane at -78 - 20℃;83%
610-81-1

4-hydroxy-2-nitroaniline

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
With hydrogen bromide Diazotization.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver und wss. HBr;
With sulfuric acid Diazotization.man versetzt mit einer konz. Kaliumbromidloesung und fuegt Kupferpulver hinzu;
Stage #1: 4-hydroxy-2-nitroaniline With hydrogen bromide; sodium nitrite In water at 0 - 10℃; for 1h;
Stage #2: With hydrogen bromide; copper(I) bromide at 40 - 45℃; for 1h;
13.1 g
554-84-7

meta-nitrophenol

7726-95-6

bromine

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
at 120 - 140℃;
2243-69-8

4-acetamido-3-nitrophenyl acetate

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous hydrobromic acid
2: aqueous HBr / Diazotization.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver und wss. HBr
View Scheme
99-09-2

3-nitro-aniline

78137-76-5

4-bromo-3-nitrophenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Diazotization
2: 120 - 140 °C / Einleiten von mit CO2 verduenntem Brom-Dampf
View Scheme
78137-76-5

4-bromo-3-nitrophenol

824-94-2

p-methoxybenzyl chloride

C14H12BrNO4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;100%
78137-76-5

4-bromo-3-nitrophenol

78389-90-9

vinyl zinc chloride

3-nitro-4-vinylphenol

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran at 100℃; for 2h;100%
1112-55-6

tetravinylsilane

78137-76-5

4-bromo-3-nitrophenol

3-nitro-4-vinylphenol

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran at 80℃; for 2h;100%
78137-76-5

4-bromo-3-nitrophenol

7486-35-3

tri-n-butyl(vinyl)tin

3-nitro-4-vinylphenol

Conditions
ConditionsYield
Stage #1: 4-bromo-3-nitrophenol; tri-n-butyl(vinyl)tin With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 4h;
Stage #2: With potassium fluoride In 1,4-dioxane at 20℃; for 2h;
100%
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Chemistry

Empirical Formula: C6H4BrNO3
Molecular Weight: 218.0049 
Structure of Phenol,4-bromo-3-nitro- (CAS NO.78137-76-5):

Index of Refraction: 1.652
Molar Refractivity: 42.37 cm3
Molar Volume: 115.89 cm3
Polarizability: 16.797×10-24cm3
Surface Tension: 64.376 dyne/cm
Density: 1.881 g/cm3
Flash Point: 124.074 °C
Enthalpy of Vaporization: 54.125 kJ/mol 
Melting Point: 144-145 ºC
Boiling Point: 281.545 °C at 760 mmHg
Vapour Pressure: 0.002 mmHg at 25°C 
Synonyms of Phenol,4-bromo-3-nitro- (CAS NO.78137-76-5): 4-Brom-3-nitrophenol