Reference

Oral and intravenous pharmacokinetics of milrinone in human volunteers

Oral and intravenous pharmacokinetics of milrinone in human volunteers. Stroshane, Ronald M.; Koss, Raymond F.; Biddlecome, Charles E.; Luczkowec, Carol; Edelson, Jerome (Dep. Drug Metab. Disposit., Sterling-Winthrop Res. Inst., Rensselaer, NY 12144, USA). J. Pharm. Sci., 73(10), 1438-41 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Thirty-nine healthy men received milrinone [78415-72-2] either orally or i.v. in two sep. double-blind, placebo-controlled studies. The mean bioavailability, based on the area under the plasma concn. vs. time curves, was 0.92. The plasma data for those subjects in the i.v. study were described by an open two-compartment model with a mean (±SD) apparent first-order terminal elimination rate const. (b) of 0.86 (±0.23) h-1, which corresponds to a half-life of 0.8 h. In the i.v. study, the renal clearance and total body clearance were 21.1 and 25.9 L/h, resp. The corresponding values in the oral study were 23.8 and 29.7 L/h. Betwen 79.9 and 84.5% of the total doses were recovered in the urine samples taken at 0-24 h.

Cardiotonic action of amrinone and milrinone

Cardiotonic action of amrinone and milrinone. Yokoda, Hiroshi; Kenmochi, Osamu (Med. Sch., Hokkaido Univ., Sapporo, Japan). Junkan Seigyo, 7(3), 883-6 (Japanese) 1986. CODEN: JUSEE7. ISSN: 0389-1844. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review, with 12 refs., of the cardiotonic mechanism of amrinone (I) [60719-84-8] and milrinone (II) [78415-72-2].