Reference

Studies on acid sludge: Part III

Studies on acid sludge: Part III. Methyl esters of sulfonic acids from ichthammols. Malik, V. P.; Chhibber, S. K.; Chadha, B. R. (Indian Inst. Pet., Dehra Dun, India). Indian J. Technol., 15(9), 393-7 (English) 1977. CODEN: IJOTA8. ISSN: 0019-5669. DOCUMENT TYPE: Journal CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Section cross-reference(s): 63 An ichthammol (I) [8029-68-3] substitute was prepd. by sulfonation of a crude oil fraction, and the Me esters of the resulting sulfonic acids were compared with those from com. I. Both prepns. had the same general properties. Synthetic I had a slightly higher content of disulfonic acids and a lower aromaticity and sulfone no., but could be satisfactorily used in medicinal formulations.

The effect of a sulfonated shale oil extract (Ichthyol) on the migration of human neutrophilic granulocytes in vitro

The effect of a sulfonated shale oil extract (Ichthyol) on the migration of human neutrophilic granulocytes in vitro. Kownatzki, E.; Uhrich, S.; Schoepf, E. (Univ. Hautklin., Freiburg D-7800, Fed. Rep. Ger.). Arch. Dermatol. Res., 276(4), 235-9 (English) 1984. CODEN: ADREDL. ISSN: 0340-3696. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The sulfonated shale oil ext. Ichthyol [8029-68-3], was studied for its effect on the migration of human neutrophilic granulocytes by the Boyden chamber technique. When presented to the cells in a concn. gradient, Ichthyol induced a directed migration. There was little or no chemokinetic effect of Ichthyol when added to the cell compartment of the Boyden chamber. The chemotactic migration towards the tripeptides, formyl-methionyl-leucyl-phenylalanine (f-MLP) and formyl-norleucyl-leucyl-phenylalanine, towards the arachidonic acid-derived eosinophil chemotactic factor released from neutrophils by the ionophore A 23187, and towards complement-derived chemotactic activity of normal human serum was inhibited or abrogated by Ichthyol. The Ichthyol effect on f-MLP chemotaxis could be partly overcome by excessive f-MLP concns. It was reversible when Ichthyol-incubated cells were washed and resuspended in regular buffer. It is suggested that various substances contained in Ichthyol interacted with either the chemotactic factors or the cell membrane or both and thus blocked cell stimulation. The results could help to explain the cell accumulation and abscess formation obsd. with Ichthyol in inflammatory skin lesions and the anti-inflammatory properties of the drug.