Detail of > 80715-22-6
- CAS Number:
- 80715-22-6
- Name:
1,3-Dioxol-2-one,4-(bromomethyl)-5-methyl-
- Superlist Name:
- 4-Bromomethyl-5-methyl-1,3-dioxol-2-one
- Formula:
- C5H5BrO3
- Molecular Structure:

- Synonyms:
- (5-Methyl-2-oxo-1,3-dioxol-4-yl)methylbromide;5-(Bromomethyl)-4-methyl-2-oxo-1,3-dioxole;
- Molecular Weight:
- 193.00
- Density:
- 1.742 g/cm3
- Boiling Point:
- 180.518 °C at 760 mmHg
- Flash Point:
- 62.976 °C
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Reference
- Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
- Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group. Christensen, Burton G. (Merck and Co., Inc. , USA). U.S. US 4479947 A 30 Oct 1984, 6 pp. Cont.-in-part of U.S. Ser. 35607-66-0 is the cas registry number of certain chemical which is used as reagents here. No. 366,036, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-545; A61K031-665; C07D499-00; C07D501-46; C07D317-24; C07D277-40. NCL: 424203000. APPLICATION: US 82-385199 7 Jun 1982. PRIORITY: US 81-282821 13 Jul 1981; US 81-285170 20 Jul 1981; US 81-324728 25 Nov 1981; US 82-344413 1 Feb 1982; US 82-366036 6 Apr 1982. 35607-66-0 which is the cas registry number of one of substances is just one of reagents here. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 The moiety, I (R = C1-6 alkyl), when esterified with a carboxylic acid-contg. drug, enhances its oral absorption. Thus, cefoxitin [35607-66-0] was esterified with (5-methyl-2-oxo-1,3-dioxolen-4-yl) Me bromide [80715-22-6] in HMPA to give cefoxitin (5-methyl-2-oxo-1,3-dioxolen-4-yl) Me ester [86005-03-0] which had better oral bioavailability in humans than cefoxitin itself. Other carboxylic drugs can be treated similarly. ..
- Cinnamidobenzoate esters
- Cinnamidobenzoate esters. Kato, Yoshika; Riku, Yuichi; Yoshinaga, Junji (Sawai Pharmaceutical Co.Several substances are used for example 80715-22-6 and 18997-19-8 which are their cas registry numbers., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 61180752 A2 13 Aug 1986 Showa, 6 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07C103-66. ICS: C07C102-00. APPLICATION: JP 85-21521 5 Feb 1985. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 1, 63 The title esters (I; R1 = alkoxyphenyl, R2 = hydrocarbon residue), effective antiallergy agents at 100 mg/kg p.o. in rats, are prepd. Thus, 1.2 mmol Me3CCO2CH2Cl and 1.2 mmol NaI were added to a soln. of 1 mmol cinnamide II and 1.2 mmol Et3N in Me2CO and refluxed 3 h to give 73% I (R1 = 3,4-dimethoxyphenyl at 2-position, R2 = Me3CCO2CH2). Two formulations contg. I were given. .
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