Reference

No protection in sheep by high-dose methylprednisolone against pulmonary microvascular injury following trauma

No protection in sheep by high-dose methylprednisolone against pulmonary microvascular injury following trauma. Smith, Lennart; Andreasson, S.; Risberg, B. (Dep. Surg., Univ. Goeteborg, Goeteborg S-413 45, Swed.). Circ. Shock, 20(4), 269-80 (English) 1986. CODEN: CRSHAG. ISSN: 0092-6213. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The osmotic reflection coeff. (s) of the pulmonary microvessels in sheep was estd. after a preparative trauma, and the effect of a single, high (30 mg/kg) dose of methylprednisolone (MP) [83-43-2] was compared with that of a dose of normal saline (S). After bilateral thoracotomies for lung lymph cannulation and placement of a balloon catheter in the left atrium, the animals were followed during anesthesia for 1 h. Left atrial pressure (Pla) was then increased and 2 levels of filtration-independent lymph to plasma protein concn. ratio (L/P) were recorded. After the operation, leukocyte and platelet counts in both groups decreased. Lung lymph flow (QL) increased during the 1st hour without hemodynamic changes, whereas L/P decreased in the MP group but was unaffected in the S group. Partial pressure or oxygen (PaO2) was spontaneously improved postoperatively in the MP group but remained unchanged in the S group. The 2 levels of filtration-independent L/P were reached at Pla 28.7 and 34.3 mm Hg in the MP group and 25.6 and 31.3 mm Hg in the S group. QL increased by 500% and 930% at the 2 levels of increased Pla with unchanged L/P at 0.44 and 0.46, resp., in the MP group. Corresponding values in the S group were 590% and 730% increases in QL with L/P values of 0.41 and 0.40, resp. The s in the MP group was 0.54, and s in the S group was 0.62, which was not significantly different. Thus, pretreatment with MP did not prevent the development of a permeability lesion following surgical pulmonary trauma, but an early minor protective effect of MP could not be ruled out.

Extended static lung preservation with hypothermia and corticosteroids

Extended static lung preservation with hypothermia and corticosteroids. Hall, Timothy S.; Baumgartner, William A.; Borkon, A. Michael; Bhayana, Ranjan; Galloway, Elizabeth; Hutchins, Grover M.; Reitz, Bruce A. (Dep. Pathol., Johns Hopkins Hosp., Baltimore, MD, USA). Surg. Forum, 37, 317-18 (English) 1986. CODEN: SUFOAX. ISSN: 0071-8041. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Hypothermia (4°) and Euro-Collins soln. adequately preserved rat lungs for ￡5 h. After 12 h of hypothermic ischemia, significant lung damage was evident during reperfusion, and the injury became severe after 24 h. Methylprednisolone [83-43-2], in pharmacol. doses, provided addnl. protection allowing adequate preservation of lung for ￡12 h.