Reference

Pseudomonas putida cell multiplication inhibition test: Weibull dose-response curve of several trifluoromethylbenzene derivatives

Pseudomonas putida cell multiplication inhibition test: Weibull dose-response curve of several trifluoromethylbenzene derivatives. Dacarro, C.; Baldi, M.; Bonferoni, M. C.; Riganti, V. (Ist. Farmacol., Univ. Pavia, Pavia 27100, Italy). Ig. Mod.Several substances with their cas registry numbers 121-50-6 and 393-77-1 may be metioned in this study., 86(3), 223-39 (Italian) 1986. CODEN: IGMPAX. ISSN: 0019-1655. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The toxicity of 8 derivs. of trifluoromethylbenzene [98-08-8] was detd. by multiplication inhibition of P. putida. Most toxic were 3,5-dinitro-4-chlorotrifluoromethylbenzene (I) [393-75-9], 2-nitrotrifluoromethylbenzene [384-22-5], and 5-amino-2-chlorotrifluoromethylbenzene [320-51-4]; moderately toxic was 3-nitro-4-chlorotrifluoromethylbenzene [121-17-5]; and least toxic were 3-nitrotrifluoromethylbenzene [98-46-4], 3,5-dinitro-4-hydroxytrifluoromethylbenzene [393-77-1], 3-amino-4-chlorotrifluoromethylbenzene [121-50-6], and 2-aminotrifluoromethylbenzene [88-17-5]. The mechanism of the toxicity is discussed. .

Cytogenetic and hygienic-toxicological standardization of aromatic amino and nitro compounds

Ilichkina, A. G.; Paskhina, M. N.; Shvartsman, P. Ya. (Leningr. Sanit.-Gig. Med. Inst., Leningrad, USSR). Mol. Mekh. Genet. Protsessov, 291-5. Edited by: Dubinin, N. P. "Nauka": Moscow, USSR. (Russian) 1976. CODEN: 34XDAP. DOCUMENT TYPE: Conference CA Section: 4 (Toxicology) When added to the food of larval and imago Drosophila, p-phenetidine [156-43-4], p-nitrophenetole [100-29-8], m-trifluoromethylaniline [98-16-8], or m-trifluoromethylnitrobenzene [98-46-4] increased the incidence of dominant lethal mutations among the offspring and increaed the percentage of unfertilized eggs. Oral administration of the arom. compds. to rats increased the incidence of chromosomal fragmentation, bridging, and rearrangement in the liver cells. Previously recommended max. permissible limits for these compds. 98-46-4 and 100-29-8 are just another two chemicals used in this study. in drinking water apparently should be revised downward. .