108962-85-2

Basic information

• Product Name: N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide
• Synonyms: N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide
• CAS NO: 108962-85-2
• Molecular Weight: 253.298
• Mol File: 108962-85-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide(108962-85-2)
• EPA Substance Registry System: N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide(108962-85-2)

Safety Data

• Hazardous Substances Data: 108962-85-2(Hazardous Substances Data)

Upstream product

• 1798-09-0 m-methoxyphenylacetic acid 
• 22483-09-6 2,2-dimethoxyethylamine 
• 6834-42-0 3-methoxyphenylacetic acid chloride 

Downstream Products

• 37682-06-7 8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine 
• 50351-80-9 7-methoxy-2,3,4,5-tetrahydro-1H-benz[d]azepine 
• 720690-73-3 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide 
• 96254-82-9 3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-8-methoxy-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 
• 85175-85-5 2,3-dihydro-8-methoxy-2-oxo-1H-3-benzazepine 

Relevant articles and documents

A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor

GSK189254 and its corresponding precursor GSK185071B were synthesized from 3-methoxyphenylacetic acid with 6-chloropyridine-3-carbolic acid or 6-chloronicotinamide in 8 and 7 steps with either 6% or 7% and either 14% or 16% yield, respectively. [11/

7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: Hit-to-lead optimization

New 7-sulfonamido-3-benzazepines 3 are disclosed as 5-HT2C receptor agonists. Appropriate substitution of the amino group (R1R2N-) gave compounds that were potent 5-HT2C agonists with minimal activation of the 5-HT2A and 5-HT2B receptors. Furthermore, representative examples had excellent in vitro ADME properties and good selectivity over ion channel activity.

SELECTIVE ESTROGEN RECEPTOR MODULATORS

The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R' represents 1 to 4 independent hydrogen atoms and the like; and R" represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.