720690-73-3 Usage
Description
GSK 189254A is a histamine H3 receptor antagonist that has been developed for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden episodes of sleep. It may also have potential therapeutic applications in the treatment of dementia and neuropathic pain. The pharmacological effect of GSK 189254A is believed to be related to its ability to increase the release of neurotransmitters in the brain, as demonstrated by microdialysis studies showing increased release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK 189254A has also shown significant improvements in the cognitive performance of rats in various paradigms, suggesting its potential for symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders.
Uses
Used in Pharmaceutical Industry:
GSK 189254A is used as a histamine H3 receptor antagonist for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and sudden episodes of sleep.
Used in Neurological Disorders Treatment:
GSK 189254A is used as a potential therapeutic agent for the treatment of dementia and neuropathic pain, due to its ability to increase the release of neurotransmitters in the brain, which may help improve cognitive function and alleviate pain.
Used in Alzheimer's Disease and Cognitive Disorders:
GSK 189254A is used as a symptomatic treatment for dementia in Alzheimer's disease and other cognitive disorders, as its effects on neurotransmitter release and cognitive performance in rats suggest potential therapeutic benefits for these conditions.
References
Medhurst, Andrew D., and A. I. J. Beresford. "GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models." Alzheimers & Dementia 321.3(2007):1032.
Plisson, Christophe, et al. "PET imaging of the CNS histamine H3 receptor using [11C] GSK189254A." Neuroimage 31.1(2006):T47-T47.
http://medkoo.com/products/10117
Check Digit Verification of cas no
The CAS Registry Mumber 720690-73-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,0,6,9 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 720690-73:
(8*7)+(7*2)+(6*0)+(5*6)+(4*9)+(3*0)+(2*7)+(1*3)=153
153 % 10 = 3
So 720690-73-3 is a valid CAS Registry Number.
720690-73-3Relevant articles and documents
A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor
Wang, Min,Gao, Mingzhang,Steele, Brandon L.,Glick-Wilson, Barbara E.,Brown-Proctor, Clive,Shekhar, Anantha,Hutchins, Gary D.,Zheng, Qi-Huang
, p. 4713 - 4718 (2012/08/13)
GSK189254 and its corresponding precursor GSK185071B were synthesized from 3-methoxyphenylacetic acid with 6-chloropyridine-3-carbolic acid or 6-chloronicotinamide in 8 and 7 steps with either 6% or 7% and either 14% or 16% yield, respectively. [11/
