37682-06-7

Basic information

• Product Name: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-
• Synonyms: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-;8-Methoxy-1H,3H,4H,5H-benzo[d]azepin-2-one;8-Methoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;1,3,4,5-tetrahydro-8-methoxy-2H-3-benzazepin-2-one;8-Methoxy-2,3,4,5-Tetrahydro-1H-3-Benzazepin-2-One
• CAS NO: 37682-06-7
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 37682-06-7.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-(37682-06-7)
• EPA Substance Registry System: 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-(37682-06-7)

Safety Data

• Hazardous Substances Data: 37682-06-7(Hazardous Substances Data)

Usage

General Description

2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy- is a chemical compound with the molecular formula C13H15NO2. It is a derivative of benzazepine and contains a tetrahydro-8-methoxy group. 2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy- is a white to off-white solid at room temperature and has a molecular weight of 217.26 g/mol. It has potential applications in pharmaceutical research and may be of interest for its biological and pharmacological properties.

Upstream product

• 4133-34-0 7-methoxyl-2-tetralone 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 108962-85-2 N-(2,2-dimethoxyethyl)-2-(3-methoxyphenyl)acetamide 
• 1798-09-0 m-methoxyphenylacetic acid 
• 85175-85-5 2,3-dihydro-8-methoxy-2-oxo-1H-3-benzazepine 

Downstream Products

• 720690-73-3 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide 
• 36133-00-3 2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol 
• 1022949-63-8 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol 
• 50351-80-9 7-methoxy-2,3,4,5-tetrahydro-1H-benz[d]azepine 
• 952710-29-1 7-methoxy-3-[2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-2.3.4.5-tetrahydro-1H-benzo[d]azepine 

Relevant articles and documents

Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin: Via iridium-catalyzed asymmetric hydrogenation

Phosphine-oxazoline (PHOX) ligands are a very important class of privileged ligands in asymmetric catalysis. A series of highly rigid oxa-spiro phosphine-oxazoline (O-SIPHOX) ligands based on O-SPINOL was synthesized efficiently, and their iridium complexes were synthesized by coordination of the O-SIPHOX ligands to [Ir(cod)Cl]2 in the presence of sodium tetrakis-3,5-bis(trifluoromethyl)phenylborate (NaBArF). The cationic iridium complexes showed high reactivity and excellent enantioselectivity in the asymmetric hydrogenation of 1-methylene-tetrahydro-benzo[d]azepin-2-ones (up to 99% yield and up to 99% ee). A key intermediate of the anti-obesity drug lorcaserin could be efficiently synthesized using this protocol.

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor

Abstract A series of novel 2,4-diaminopyrimidine compounds bearing bicyclic aminobenzazepine were synthesized and evaluated for their anti-ALK activities. The activities of these compounds were confirmed in both enzyme- and cell-based ALK assays. Amongst

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat a